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Association between serum total cholesterol levels and Crohn’s clinical disease severity: a retrospective cross-sectional study

Abstract: This retrospective cross-sectional study aimed to investigate the relationship between serum total cholesterol (TC) levels and the clinical activity of Crohn’s disease…

Date: 2025-11-27

Baseline AHR expression shapes immune response to pharmacological modulation in PBMCs from pancreatic cancer patients

Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immunotherapy because of its highly immunosuppressive tumor microenvironment. Aryl hydrocarbon…

Date: 2025-11-27

Associations between metabolic-inflammatory biomarkers and Helicobacter pylori infection: an interpretable machine learning prediction approach

Abstract: This study investigated the association between metabolic-inflammatory markers and Helicobacter pylori (HP) infection using interpretable machine learning models, with a…

Date: 2025-11-27

Construction and validation of a transmembrane 4 superfamily-related genes prognostic model for esophageal squamous cell carcinoma

Abstract: Esophageal squamous cell carcinoma (ESCC), a virulent form of cancer, markedly diminishes prospects for patient survival. The transmembrane 4 superfamily ( TM4SF…

Date: 2025-11-27

Mendelian randomization integrated with multi-omics analysis identifies TNIK as a key gene in gut microbiota-induced IBD development

Abstract: Dysbiosis of the gut microbiota (GM) has been linked to inflammatory bowel disease (IBD), yet its associated molecular mechanisms remain poorly defined. Identifying…

Date: 2025-11-27

Association between preoperative platelet count and transjugular intrahepatic portosystemic shunt procedure-related hemorrhage in cirrhotic patients: a retrospective study

Abstract: Transjugular intrahepatic portosystemic shunt (TIPS) is a high-bleeding-risk vascular intervention. The association between TIPS-related hemorrhage and preprocedural…

Date: 2025-11-27

Epilepsy-associated CHD2 missense variants and optimization strategies for genetic diagnosis: a comparative analysis of algorithms

Abstract: The CHD2 gene is one of the most common causative genes of developmental and epileptic encephalopathy (DEE). With the advent of high-throughput sequencing, identifying…

Date: 2025-11-27

Videonystagmography features and clinical symptoms correlate with Parkinson's clinical subtypes

Abstract: Analyzing the differences in video-nystagmography (VNG) parameters among Parkinson's disease (PD) patients with distinct motor subtypes and evaluate the correlation…

Date: 2025-11-27

Administration of eptifibatide as rescue therapy during mechanical thrombectomy in acute ischemic stroke

Abstract: The success of the technical implementation of mechanical thrombectomy (MT) depends on many factors. Considering the experience of the interventional radiologist and the…

Date: 2025-11-27

SAFE-CGRP study: multicenter retrospective evaluation of the safety of CGRP pathway–targeting monoclonal antibodies in migraine with relevant comorbidities or conditions excluded from trials

Abstract: Monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP) have shown efficacy in the treatment of migraine. However, certain comorbidities have been…

Date: 2025-11-27