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Sex differences in pediatric major depressive episodes: a cross-sectional study on psychiatric symptoms in early-onset mood disorders

Abstract: Background: Sex differences in psychiatric symptoms among children and adolescents with a major depressive episode (MDE) are less studied than among adults. Previous…

Date: 2025-04-25

The impact of a home visiting program on the care environment of Brazilian adolescent mothers - an descriptive exploratory study

Abstract: Background: There is evidence of a link between the environment and child development (CD) in early childhood, justifying the importance of studying the characteristics…

Date: 2025-04-25

Effect of diabetes mellitus on physical function in patients with osteoarthritis: a cross-sectional observational study

Abstract: Background: Osteoarthritis (OA) is a common chronic disease among the elderly, causing pain, functional limitations, and a decline in quality of life. Diabetes mellitus…

Date: 2025-04-25

Modified transforaminal epidural steroid injection combined with pulsed radiofrequency: an effective treatment measure for lumbar radiculopathy

Abstract: Background: Lumbar disc herniation (LDH) is a prevalent condition encountered in the clinical diagnosis and management of spinal surgery. Certain people may experience…

Date: 2025-04-25

Development of a prediction model integrating PD-1 and ICOS for early differential diagnosis between autoimmune and viral encephalitis

Abstract: Background: Early diagnosis and treatment for encephalitis are crucial for improving patient outcomes and reducing the economic burden, especially given the overlapping…

Date: 2025-04-25

Molecular characterization and immune role of TLR7 in Labeo rohita

Abstract: Background: Toll-like receptors (TLRs) play a vital role in the immune response by recognizing pathogen-associated molecular patterns (PAMPs) and triggering signaling…

Date: 2025-04-25

Analysis of the impact of rotation error on PTV margins in multiple brain metastases fractionated stereotactic radiotherapy based on single-isocenter multi-target technique

Abstract: Background: Rotational error cannot be overlooked in single-isocenter multi-target (SIMT) stereotactic radiotherapy. This retrospective study aimed to evaluate the…

Date: 2025-04-25

Extensive genotype-phenotype heterogeneity in renal cell carcinoma - a proof-of-concept study

Abstract: Background: Renal cell carcinoma (RCC) is characterized by a high degree of genomic but also functional intratumoral heterogeneity (ITH). Mutations in VHL, chromatin…

Date: 2025-04-25

Global, regional, and national burden and risk factors of ischemic heart disease, 1990–2021: an analysis of the global burden of disease study

Abstract: Background: With a rapidly growing and aging world population, ischemic heart disease (IHD) remains a major burden. This study aimed to reassess the prevalence trend of…

Date: 2025-04-25

Association of postural orthostatic tachycardia syndrome, hypermobility spectrum disorders, and mast cell activation syndrome in young patients; prevalence, overlap and response to therapy depends on the definition

Abstract: Background: The close association of syndromes of orthostatic intolerance with and without postural orthostatic tachycardia syndrome (POTS) with Joint Hypermobility…

Date: 2025-04-25