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The administration sequences of immune checkpoint inhibitors and chemotherapy cause discrete efficacy when treating non-small cell lung cancer: a retrospective study

Abstract: Background: Immune checkpoint inhibitors (ICIs) combined with chemotherapy have become a standard first-line treatment for advanced non-small cell lung cancer (NSCLC).…

Date: 2025-04-28

Joint and independent associations of dietary vitamin intake and prevalence of cardiovascular disease in chronic kidney disease subjects: a cross-sectional analysis

Abstract: Background: Currently, the joint and independent effects of intake of multiple dietary vitamins (including vitamin A, B1, B2, B6, B12, C, D, E, and K) on the prevalence…

Date: 2025-04-28

Can we know more about atherosclerosis in cyanotic patients with congenital heart disease—the potential role of sphingosine-1-phosphate?

Abstract: Background and aims: Progress in cardiology has extended the lifespan of patients with congenital heart defects (CHD). Cyanotic patients are exposed to typical diseases…

Date: 2025-04-28

Monocarboxyoctyl phthalate is associated with platelet count: evidence from a large cross-sectional study

Abstract: Introduction: Phthalates are environmental pollutants that are harmful to human health. However, the impact of phthalate on platelet count remains unclear. This study…

Date: 2025-04-25

Fortified Withaferin A accelerates the transition from fibrovascular to bone remodeling phase during endochondral bone formation to promote ossification

Abstract: Introduction: This study shows that Fortified Withaferin A (FWA, 10% w/w) accelerates bone healing, advancing from the fibrovascular to bone remodeling stage within 12…

Date: 2025-04-25

In vivo RNAi screen and validation reveals Ngp, Hba-a1, and S100a8 as novel inhibitory targets on T lymphocytes in liver cancer

Abstract: Background: Hepatocellular carcinoma (HCC) represents the third deadliest cancer worldwide with limited treatment options. Immune checkpoint inhibitors (ICIs) have…

Date: 2025-04-25

Outcomes and risk factors of COVID-19 in patients with bullous pemphigoid: a cross-sectional study

Abstract: Background: The outcomes of coronavirus disease 2019 (COVID-19) in patients with bullous pemphigoid (BP) remain insufficiently understood. This study aimed to evaluate…

Date: 2025-04-25

Family relationships and personality traits of postural tachycardia syndrome

Abstract: Introduction: Orthostatic intolerance is the name of the disease in Europe and the United States; however, in Japan, it is commonly known as orthostatic dysregulation…

Date: 2025-04-25

Culinary medicine in medical education: a pilot study targeting cancer risk reduction strategies through culinary and lifestyle medicine education

Abstract: Introduction: Culinary Medicine (CM) is an avenue for interdisciplinary nutrition education intervention utilizing the expertise of dietitians, physicians, and other…

Date: 2025-04-25

Single-cell combined transcriptome probes prognostic mechanisms of sialylation-related genes in cervical cancer

Abstract: Introduction: Sialylation has been linked to cervical dysplasia, while its involvement in cervical cancer is uncertain. Hence , the aim of this study was to develop a…

Date: 2025-04-25