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The impact of antibiotic use on outcomes of relapsed/refractory multiple myeloma patients treated with CAR-T therapy

Abstract: Background: In recent years, chimeric antigen receptor (CAR)-T cell therapy has achieved tremendous efficacy in relapsed/refractory multiple myeloma (R/R MM). However,…

Date: 2025-04-17

Global trends and disparities in the burden of heart failure caused by chronic kidney disease: an analysis of the global burden of disease study 2021

Abstract: Background: Heart failure (HF) is a major public health concern, and chronic kidney disease (CKD) plays a significant role in its pathogenesis. Understanding the trends…

Date: 2025-04-17

Long-term outcomes of congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a retrospective study from a tertiary care center in Saudi Arabia

Abstract: Introduction: Data on congenital adrenal hyperplasia (CAH) disorders in the Saudi population are limited. This retrospective study assessed the clinical characteristics…

Date: 2025-04-17

No, either or both parents with metabolic syndrome: comparative study of its impact on sons and daughters

Abstract: Background: Metabolic syndrome (MetS) is known to have parental influence on children’s metabolic health, increasing the risk for the cardiometabolic diseases. However,…

Date: 2025-04-17

Concomitant autoimmunity and late cancers in adult-onset immunodeficiency due to neutralizing anti-IFN-? autoantibodies

Abstract: Background: Opportunistic intramacrophagic infections are well-characterized in adult-onset immunodeficiency associated with neutralizing anti-IFN-? autoantibodies…

Date: 2025-04-17

Extreme temperatures modulate gene expression in the airway epithelium of the lungs in mice and asthma patients

Abstract: Background: The objective of this study was to examine the effects of extreme temperatures on the gene signature and pathways of airway epithelial cells in mice and…

Date: 2025-04-17

Prenatal opioid exposure alters pain perception and increases long-term health risks in infants with neonatal opioid withdrawal syndrome

Abstract: Background: Opioids are often prescribed for pain relief, yet they pose risks such as addiction, dependence, and overdose. Pregnant women have unique vulnerabilities to…

Date: 2025-04-17

Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma

Abstract: Background: Disulfidptosis is an emerging type of programmed cell death related to ROS accumulation and aberrant disulfide bond formation. Multiple myeloma (MM) is the…

Date: 2025-04-16

Clinical efficacy of Bufei Yishen and Qutan Tongluo Cream on the treatment of patients with stable chronic obstructive pulmonary disease

Abstract: Background: Traditional Chinese medicine has been used for the treatment of chronic obstructive pulmonary disease (COPD). However, the effect of Bufei Yishen and Qutan…

Date: 2025-04-16

Increasing donor kidney age significantly aggravates the negative effect of pretransplant donor-specific anti-HLA antibodies on kidney graft survival

Abstract: Background and hypothesis: The presence of donor-specific anti-HLA antibodies before kidney transplantation (preDSAs) is associated with decreased graft survival. The…

Date: 2025-04-16