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Heterogeneity of ?? T-cell subsets and their clinical correlation in patients with AML

Abstract: Background: ?? T cells are integral elements of the immune system and have shown therapeutic potential in the treatment of acute myeloid leukemia (AML). Nevertheless,…

Date: 2025-04-01

A comparative analysis of lesional skin, sentinel flap, and mucosal biopsies in assessing acute face transplant rejection

Abstract: Background: Face transplant rejection is primarily monitored through skin biopsies, but mucosal tissue may detect immune rejection events missed by skin biopsies.

Date: 2025-04-01

Anxiety disorders in patients with thyroid nodules vs. thyroid cancer: a retrospective cohort study

Abstract: Background: Thyroid nodules, often discovered incidentally, typically require long-term monitoring and may contribute to psychological distress. Despite their…

Date: 2025-04-01

Impact of single nucleotide polymorphisms of immunomodulatory factors on treatment response and prognosis in acute myeloid leukemia

Abstract: Background: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by poor overall survival (OS). The impaired function, altered phenotype, and abnormal…

Date: 2025-03-31

Monitoring sexual hormones in women going to high altitude—a pilot study

Abstract: Background: The susceptibility to acute mountain sickness (AMS) in relation to sexual hormones in women remains elusive, partly because hormones could not be…

Date: 2025-03-31

Improvement in breast cancer survival across molecular subtypes in Hungary between 2011 and 2020: a nationwide, retrospective study

Abstract: Background: Despite well-documented clinical differences across breast-cancer (BC) molecular subtypes and relevant changes in therapeutic interventions over the past…

Date: 2025-03-31

Post-carvedilol myocardial function in cats with obstructive hypertrophic cardiomyopathy

Abstract: Introduction: Hypertrophic cardiomyopathy (HCM) is the most prevalent cardiac disease in cats, and one phenotype includes obstructive HCM with dynamic left ventricular…

Date: 2025-03-28

Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation

Abstract: Background and purpose: Promoting adaptive immunity with ICIs has drastically improved melanoma prognosis, but not for all patients. Some cases relapse in the first few…

Date: 2025-03-28

Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion

Abstract: Background: Anti-CD19 chimeric antigen receptor T (CAR-T) cell therapy has proven effective for treating relapsed or refractory acute B cell leukemia. However,…

Date: 2025-03-27