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Combining PCR to detect junction fragments and deleted exons in the prenatal diagnosis of BMD can effectively identify maternal cell contamination

Abstract: The junction fragment after the DMD gene deletion has been identified as a new specific DNA sequence formed by the reconnection of the ends. Our study aims to report a…

Date: 2025-09-03

A clinical study incorporating multimodal 18 F-FDG PET/CT metabolic parameters, genetic markers, and clinical characteristics for the evaluation and prediction of treatment efficacy and prognosis in Langerhans cell histiocytosis

Abstract: Langerhans cell histiocytosis (LCH) is a rare clonal proliferative disorder characterized by the infiltration of pathological Langerhans cells into multiple organs,…

Date: 2025-09-03

Urban–rural social security, adult children’s layoffs and older parents’ health

Abstract: Aging population and rising unemployment risks have emerged as dual challenges for governments worldwide. Using China’s 1990s state-owned enterprise layoffs as a natural…

Date: 2025-09-03

Emergence of two novel viruses in Tibetan pigs with porcine diarrheal disease on the Tibetan plateau of southwest China

Abstract: Porcine diarrheal disease is a major cause of morbidity in Tibetan piglets, however, the causative agents of this disease are rarely reported. Here, the viral diversity…

Date: 2025-09-03

Prevalence and sociodemographic characteristics of parents among patients treated in adult psychiatric hospitals – a register-based nationwide study

Abstract: Children of parents with mental illness face heightened risks of adverse health, social, and educational outcomes. Yet, families affected by parental mental illness are…

Date: 2025-09-03

Risk factors for emergency cesarean delivery in patients with placenta accreta spectrum: a multicenter retrospective cohort study

Abstract: Pregnant women with placenta accreta spectrum (PAS), particularly those with placenta increta or placenta percreta, undergoing emergency cesarean section are at a high…

Date: 2025-09-03

NADH supplementation improves human oocyte maturation and developmental competence of resulting embryos in controlled ovarian hyperstimulation cycles: a pilot study implicating the CDK2/GAS6 signaling pathway

Abstract: Mitochondrial dysfunction in immature oocytes remains a critical barrier to successful in vitro maturation (IVM), particularly in cases of diminished ovarian reserve.…

Date: 2025-09-03

Systemic immune inflammatory index and mortality in chronic kidney disease

Abstract: Chronic kidney disease (CKD) is common and linked to higher mortality rates, but its relationship with the systemic immunoinflammatory index (SII) remains unclear,…

Date: 2025-09-03

Prevalence of antenatal depression and its association with adverse childhood experiences: a cross- sectional study at Hospital Canselor Tuanku Muhriz, Kuala Lumpur

Abstract: Emerging evidence suggests a link between adverse childhood experiences (ACEs) and antenatal depression, with a higher number of maternal ACEs associated with increased…

Date: 2025-09-03

Inhibitory and excitatory conditioned cues associated with alcohol differentially modulate the nucleus accumbens shell: involvement of 5-HT 7 receptors

Abstract: The ability of conditioned cues to evoke drug craving is considered a critical factor precipitating relapse of drug use. The nucleus accumbens shell (AcbSh) is a…

Date: 2025-09-03