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Predictors of response to anti-VEGF combined with laser therapy in severe non-proliferative diabetic retinopathy: development and validation of a nomogram model from retrospective data

Abstract: Anti-vascular endothelial growth factor (anti-VEGF) and laser combination therapy demonstrates variable efficacy in severe non-proliferative diabetic retinopathy, with…

Date: 2025-09-03

Diagnostic lncRNA biomarkers and immune-related ceRNA networks for osteonecrosis of the femoral head in metabolic syndrome identified by plasma RNA sequencing and machine learning

Abstract: Osteonecrosis of the femoral head (ONFH) is a disabling orthopedic condition that remains challenging to diagnose at an early stage. Recent evidence suggests that immune…

Date: 2025-09-03

Application of anterior minimally invasive clamping technique combined with lower extremity axial bone traction device in irreducible intertrochanteric fractures

Abstract: This study aims to evaluate the effectiveness of the anterior minimally invasive clamping technique in conjunction with a lower extremity axial bone traction device for…

Date: 2025-09-03

Short-term air pollution and fracture admissions in Beijing

Abstract: Limited evidence exists on the links between ambient air pollution and fractures. This study aimed to investigate the association between short-term exposure to criteria…

Date: 2025-09-03

Association between blood cobalt ion concentrations and anemia and cardiovascular diseases: novel evidence of toxicity resulting from metal implants

Abstract: Cobalt ions released from metal objects pose potential systemic toxicity risks, yet comprehensive epidemiological evidence linking blood cobalt ion concentrations with…

Date: 2025-09-03

Dynamic stability of gut microbiota in elite volleyball athletes: microbial adaptations during training, competition and recovery

Abstract: To examine how different weekly training and competition schedules influence gut microbiota composition in elite volleyball players, investigating the relationship…

Date: 2025-09-03

Synergistic role of blood-labyrinth barrier permeability and endolymphatic hydrops: a comparative perspective in Ménière’s disease and vestibular migraine

Abstract: This study compares the delayed gadolinium-enhanced MRI characteristics of Ménière’s disease (MD) and vestibular migraine (VM) to develop a multiparametric model that…

Date: 2025-09-03

IONPs combined with cytarabine downregulated IFITM3 expression to inhibit acute myeloid leukemia

Abstract: Acute myeloid leukemia (AML) is the most prevalent acute leukemia in adults. While conventional therapies can induce remission disease frequently relapses with fatal…

Date: 2025-09-03

Chronic stress synergizes with Listeria monocytogenes to promote intestinal adenomagenesis via myeloid-derived suppressor cells

Abstract: Chronic stress and gut dysbiosis are established risk factors for colorectal adenocarcinoma, yet their synergistic effects on the development of intestinal precancerous…

Date: 2025-09-03

Risk factors for thrombotic events in Philadelphia chromosome-negative myeloproliferative neoplasms: a retrospective analysis of 336 cases

Abstract: Thrombotic events are one of the main factors affecting the survival of patients with Philadelphia chromosome-negative (Ph-) myeloproliferative neoplasms (MPNs).…

Date: 2025-09-02