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Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients

Abstract: Introduction: Recent surveillance has identified the emergence of the SARS-CoV-2 Omicron ariant, which exhibits the ability to evade multiple neutralizing antibodies…

Date: 2025-03-18

Direct economic burden of acute coronary syndromes in the Portuguese National Health Service—facts and trends between 2002 and 2022

Abstract: Aim: We estimated the average direct cost per Acute Coronary Syndromes (ACS) in-patient episodes by diagnosis, namely ST-elevation myocardial infarction (STEMI), non-ST…

Date: 2025-03-18

Electrochemical skin conductance: a tool for risk stratification and early anticipation of diabetic foot ulcers

Abstract: Introduction: Diabetic foot ulcers (DFUs) are a major complication of diabetes, leading to high morbidity, mortality, and healthcare costs. Current DFU risk…

Date: 2025-03-17

Intrapatient tacrolimus variability is associated with medical nonadherence among pediatric kidney transplant recipients

Abstract: Background: Long-term survival of kidney allografts is limited by multiple factors, including nonadherence. High intrapatient variability in tacrolimus levels (?30%) is…

Date: 2025-03-17

Real-life effectiveness of once-daily single-inhaler triple therapy (FF-UMEC-VI) after switching from dual therapy (ICS-LABA) in patients with symptomatic asthma: trelegy ellipta for real asthma control study

Abstract: Introduction: A well-designed, protocol-driven randomized controlled trial (RCT) has demonstrated the efficacy of fluticasone furoate-umeclidinium-vilanterol…

Date: 2025-03-17

Medicines not recommended for inclusion in the who essential medicines list: a retrospective observational study

Abstract: Background: The WHO Model List of Essential Medicines (EML) includes those medicines that offer the best health payback for individuals and health systems. It serves as…

Date: 2025-03-17

Eliglustat and cardiac comorbidities in Gaucher disease: a pharmacogenomic approach to safety and efficacy

Abstract: Introduction: Gaucher disease (GD), a lysosomal storage disorder, results from the accumulation of glycosphingolipids due to deficient lysosomal glucocerebrosidase…

Date: 2025-03-17