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Assessing the association between the non-HDL to HDL cholesterol ratio and NAFLD in Chinese adults: concentrate on gout populations

Abstract: The coexistence and synergistic relationship between Nonalcoholic fatty liver disease (NAFLD) and gout necessitate an investigation into the risk factors for NAFLD among…

Date: 2025-09-01

Depression-associated reductions in putaminal volume are accompanied by a shift from matrix-like to striosome-like structural connectivity

Abstract: The striatum is among the most studied brain regions in Major Depressive Disorder (MDD) due to its involvement in reward, motivation, and executive functions. The…

Date: 2025-09-01

Development and validation of a nomogram for predicting early-onset severe intraventricular hemorrhage in extremely preterm infants

Abstract: Severe intraventricular hemorrhage (IVH) remains a major complication in extremely preterm infants, with significant clinical implications. We aimed to develop and…

Date: 2025-09-01

Health system resilience and pandemic response: a comparative analysis of China, Singapore, the U.S., and the U.K.

Abstract: Infectious disease outbreaks have imprinted unprecedentedly on global economies, societies, politics, and healthcare systems. The COVID-19 pandemic underscored critical…

Date: 2025-09-01

Pembrolizumab in the treatment of non-small cell lung cancer—experiences from clinical practice

Abstract: Immune checkpoint inhibitors (ICIs) have become the standard first-line treatment for patients with advanced or metastatic non-small cell lung cancer (NSCLC) without…

Date: 2025-09-01

Gut microbiome with RAS mutation and chemotherapy response in patients with advanced or metastatic colorectal cancer: a pilot, exploratory study

Abstract: The gut microbiome plays a pivotal role in tumor–microenvironment interactions, inflammation modulation, and immune regulation, thereby affecting the response to…

Date: 2025-09-01

Impact of hospital payment reform on rational use of antibiotics: a natural experiment

Abstract: While numerous studies have examined the effects of diagnosis-related groups (DRG) payment on hospital healthcare, evidence regarding its impact on the quality of…

Date: 2025-09-01

Effects of parthenolide on amino acid metabolism and oxidative stress in lung adenocarcinoma based on quantitative proteomic analysis, targeted amino acid metabolomics, network pharmacology, and experimental validation

Abstract: Lung adenocarcinoma (LUAD) causes millions of deaths annually worldwide. Parthenolide (PTL), extracted from traditional Chinese herbal medicines, has various biological…

Date: 2025-09-01

Clinical value at baseline and follow-up of myeloperoxidase-antibodies in ANCA-associated vasculitis

Abstract: ANCA-associated vasculitides (AAV) are potentially organ- or life-threatening disorders that can cause irreversible damage if treatment is not started in time. The…

Date: 2025-09-01

Patient satisfaction and pain relief following radiofrequency rhizotomy for trigeminal neuralgia: a prospective cohort study

Abstract: Trigeminal neuralgia (TN) causes severe facial pain and affects quality of life. Radiofrequency rhizotomy (RFR) is often used when medications fail. This multicenter…

Date: 2025-09-01