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Time to viral load re-suppression and its predictors among adult patients on second-line anti-retro viral therapy in northeastern Ethiopia: multi-center prospective follow-up study

Abstract: Background: Despite the increasing number of patients on second-line antiretroviral therapy in low-income countries such as Ethiopia, there is limited evidence regarding…

Date: 2025-03-10

Wnt/?-catenin pathway activation is associated with glucocorticoid secretion in adrenocortical carcinoma, but not directly with immune cell infiltration

Abstract: Background: In advanced adrenocortical carcinoma (ACC), the response rate to immune checkpoint inhibition (ICI) is only ~15%. Glucocorticoid (GC) secretion and the…

Date: 2025-03-10

Post-traumatic stress disorder and its associated factors among internally displaced people due to conflict in Northwest Ethiopia

Abstract: Background: Post-traumatic stress disorder (PTSD) is a mental health condition that develops after being exposed to trauma, such as experiencing or witnessing…

Date: 2025-03-10

Effects of couple-based violence prevention education on male partners' knowledge, attitudes and controlling behavior related to intimate partner violence in rural Ethiopia: a cluster randomized controlled trial

Abstract: Background: Supportive attitudes toward wife-beating and the experience of controlling behavior from husbands have been known to increase the risks of intimate partner…

Date: 2025-03-10

Clinical association of body symptoms and primary dysmenorrhea among young and middle-aged women: an observational study

Abstract: Background: The mechanism of primary dysmenorrhea remains unraveled. Body symptoms not related to menstrual cycle may indicate the potential mechanism of primary…

Date: 2025-03-10

Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma

Abstract: Background: Hepatocellular carcinoma (HCC) is the third most prevalent cause of cancer-related mortality globally and the sixth most common cancer overall. It is…

Date: 2025-03-10

Comprehensive integration of diagnostic biomarker analysis and immune cell infiltration features in sepsis via machine learning and bioinformatics techniques

Abstract: Introduction: Sepsis, a critical medical condition resulting from an irregular immune response to infection, leads to life-threatening organ dysfunction. Despite medical…

Date: 2025-03-10

The relationship between advanced glycation end products, metabolic metrics, HbA1c, and diabetic nephropathy

Abstract: Background: In this cross-sectional study, we aim to investigate the value of non-invasive advanced glycation end products (AGEs) detection in the early screening of…

Date: 2025-03-07

TMED9: a potential therapeutic target and prognostic marker in glioma and its implications across pan-cancer contexts

Abstract: Background: The escalating global cancer burden, projected to reach 35 million new cases by 2050, underscores the urgent need for innovative cancer biomarkers to improve…

Date: 2025-03-07

Follow-up of transcatheter closure of congenital heart disease complicated with pulmonary arterial hypertension in children

Abstract: Background: Transcatheter closure is now the preferred treatment for congenital heart disease complicated with pulmonary arterial hypertension (CHD-PAH), but its…

Date: 2025-03-07