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Efficacy and influencing factors of immunosuppressive therapy combined with or without eltrombopag in children with severe aplastic anemia

Abstract: To compare the efficacy of eltrombopag (EPAG) combined with standard immunosuppressive therapy (IST), EPAG with cyclosporine or cyclosporine alone in children with…

Date: 2025-11-21

Efficacy and safety of postoperative radiotherapy in locally advanced esophageal squamous cell carcinoma patients with pathologic incomplete response after neoadjuvant immunochemotherapy: a retrospective cohort study

Abstract: Neoadjuvant immunotherapy combined with chemotherapy (NICT) has demonstrated a good pathological complete response (pCR) rate and prognosis in locally advanced…

Date: 2025-11-21

Worse prognosis of local and locally advanced head and neck Merkel cell carcinoma: Is it time to change the treatment paradigm?

Abstract: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer with high metastatic potential. The impact of primary tumor location on survival outcomes…

Date: 2025-11-21

Sex-specific CT-derived muscle and fat phenotypes in colon cancer: implications for nutritional and metabolic assessment

Abstract: Computed Tomography (CT)-derived analysis of Body Composition (BC) provides detailed phenotyping of skeletal muscle and adipose tissue, offering insight into nutritional…

Date: 2025-11-21

Impact of inflammatory and nutritional parameters on mortality in cardiovascular multimorbidity: a comprehensive prognostic analysis based on two datasets

Abstract: Cardiovascular multimorbidity (CMM), defined as the coexistence of multiple cardiometabolic diseases, has posed an escalating global health burden associated with…

Date: 2025-11-21

Predictors of B-line count in hospitalized patients with COVID-19

Abstract: B-lines on lung ultrasound (LUS) are nonspecific signs of increased lung density, which can be secondary to pulmonary congestion, pneumonia, or fibrosis. While its use…

Date: 2025-11-21

Correlation between vascular adhesion protein-1 and major adverse cardiovascular events in patients with atrial fibrillation

Abstract: VAP-1, an inflammation-induced endothelial molecule, is implicated in cardiovascular diseases, but its role in AF is unclear. This study aimed to explore the…

Date: 2025-11-21

Retrospective analysis of omega-3 fatty acids and the DASH diet in hyperlipidemia and hypertension management among obese individuals

Abstract: Cardiovascular disease, obesity, high blood pressure, and abnormal lipid profiles are public health issues. Dietary therapies like the DASH diet and omega-3 supplements…

Date: 2025-11-21

Suppression of NK cell-mediated immunosurveillance by IL-35 drives tumor progression in EGFR-mutant non-small cell lung cancer

Abstract: Interleukin-35 (IL-35) is an added member of the IL-12 heterodimeric cytokine family, composed of two subunits: EBI3 and P35 subunits, implicated in tumor immune…

Date: 2025-11-20

Integration of intratumoral/peritumoral radiomics and deep learning for predicting overall survival in non-small cell lung cancer patients: a multicenter study

Abstract: Prognostic assessment of non-small cell lung cancer (NSCLC) relies on TNM staging, yet tumor heterogeneity limits its accuracy. This study aimed to develop a model for…

Date: 2025-11-20