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Vonoprazan-related adverse events: a pharmacovigilance study based on the FDA adverse event reporting system

Abstract: This study comprehensively evaluated the safety profile of Vonoprazan using data from the FDA Adverse Event Reporting System (FAERS) from the first quarter (Q1) of 2023…

Date: 2025-12-19

Dietary vitamin B9 intake linked to drug-resistant epilepsy risk in western Chinese adults: exploring underlying metabolomic mechanisms

Abstract: Approximately 30% of epilepsy patients develop drug-resistant epilepsy (DRE), underscoring the need for adjunctive therapies. While dietary interventions like the…

Date: 2025-12-19

Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages

Abstract: PANoptosis is a form of inflammatory cell death that exhibits simultaneous activation of pyroptosis, apoptosis and necroptosis signaling. Disulfiram is a clinically used…

Date: 2025-12-19

Plasma cell-free DNA genome-wide methylation profiling enables detection and activity assessment in systemic lupus erythematosus

Abstract: Cell-free DNA (cfDNA) has emerged as a promising non-invasive biomarker in precision medicine and is increasingly recognized as relevant to relevance in systemic lupus…

Date: 2025-12-19

Impact of inotuzumab ozogamicin as bridging therapy and tumor burden in CAR-T therapy for B-acute lymphoblastic leukemia

Abstract: Inotuzumab ozogamicin is increasingly being used as bridging therapy (BT) prior to chimeric antigen receptor T-cell (CAR-T) in relapsed/refractory B-cell acute…

Date: 2025-12-18

Pediatric acute lymphoblastic leukemia relapse and prognosis: key predictors and therapeutic implications

Abstract: Pediatric acute lymphoblastic leukemia (ALL), the most common childhood malignancy, achieves >95% 5-year survival with risk-adapted therapies. Nonetheless, 10%–15% of…

Date: 2025-12-18

Burden of multiple myeloma in Asian countries from 1990 to 2021 and trend prediction for 2050: an analysis based on the Global Burden of Disease Study 2021

Abstract: Multiple myeloma (MM) poses a growing challenge to global public health, with regional disparities in disease burden becoming increasingly prominent. As the most…

Date: 2025-12-18

Case Report: Ectopic Cushing’s syndrome caused by a pancreatic neuroendocrine tumor managed through dual steroidogenesis inhibition and endoscopic ultrasound-guided ethanol ablation

Abstract: Ectopic adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome (EAS) is a rare complication of neuroendocrine tumors (NETs). Severe hypercortisolism (SH)…

Date: 2025-12-18

Comparative study of 5% permethrin, 10% neem leaf extract, and 10% brotowali stem extract for scabies treatment

Abstract: Scabies, a contagious skin infestation caused by Sarcoptes scabiei var. hominis , remains a significant public health issue, particularly in developing countries.…

Date: 2025-12-18

Knowledge, attitudes, and practices of hand eczema patients in Guangdong, China

Abstract: Hand eczema is a common, debilitating condition affecting quality of life. This study aimed to assess the knowledge, attitudes, and practices (KAP) of patients with hand…

Date: 2025-12-18