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Systematic identification of therapeutic targets for coronary artery calcification: an integrated transcriptomic and proteomic Mendelian randomization

Abstract: Background: Coronary artery calcification (CAC) is associated with an increased risk of mortality and cardiovascular events. However, none therapeutic drugs have been…

Date: 2024-10-25

Correlation between obstructive sleep apnea and weight-adjusted-waist index: a cross-sectional study

Abstract: Background: Obesity is recognized as a prominent factor in the pathogenesis of obstructive sleep apnea (OSA). The weight-adjusted-waist index (WWI) has emerged as a…

Date: 2024-10-23

Semi-quantitative CT score reflecting the degree of pulmonary infection as a risk factor of hypokalemia in COVID-19 patients: a cross-sectional study

Abstract: Background: Hypokalemia is a common electrolyte disorder observed in patients afflicted with coronavirus disease 2019 (COVID-19). When COVID-19 is accompanied by…

Date: 2024-10-21

Genetically mimicked effects of thyroid dysfunction on diabetic retinopathy risk: a 2-sample univariable and multivariable Mendelian randomization study

Abstract: Background: Thyroid dysfunction exhibits a heightened prevalence among people with diabetes compared to those without diabetes. Furthermore, TD emerges as a notable…

Date: 2024-10-21

Pancreatic ?-cells package double C2-like domain beta protein into extracellular vesicles via tandem C2 domains

Abstract: Introduction: Double C2-like domain beta (DOC2B) is a vesicle priming protein critical for glucose-stimulated insulin secretion in ?-cells. Individuals with type 1…

Date: 2024-10-21

Single center experience in localization of insulinoma by selective intraarterial calcium stimulation angiography - a case series of 15 years

Abstract: Background: Insulinomas are rare insulin-secreting neuroendocrine neoplasms of the pancreas. First-line treatment is the surgical removal of the tumor, however, the…

Date: 2024-10-21

The immunological and prognostic significance of the diabetes mellitus-related gene WFS1 in endometrial cancer

Abstract: Background: Diabetes is associated with the incidence and prognosis of various malignancies, most notably endometrial cancer (EC). This study investigated the connection…

Date: 2024-10-16

Obesity-related renal dysfunction: gender-specific influence of visceral adiposity and early impact of metabolic and bariatric surgery

Abstract: Introduction: Renal dysfunction is a recognized complication of obesity with an incompletely characterized pathophysiology. Improvement of glomerular filtration rate…

Date: 2024-10-14

Dietary intakes of branch chained amino acids and obesity risk among Chinese gestational diabetes women

Abstract: Introduction: Epidemiological studies have assessed the correlation between daily dietary branch chain amino acid (BCAA) intakes and the risk of obesity, however, the…

Date: 2024-10-10

Standardizing CRISPR-Cas13 knockdown technique to investigate the role of cdh2 gene in pituitary development through growth hormone expression and transcription factors

Abstract: Introduction: Congenital hypopituitarism (CH) is characterized by the deficiency of pituitary hormones. Among CH patients, 85% lack a molecular diagnosis. Whole Exome…

Date: 2024-10-10