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Unraveling the role of ADAMs in clinical heterogeneity and the immune microenvironment of hepatocellular carcinoma: insights from single-cell, spatial transcriptomics, and bulk RNA sequencing

Abstract: Background: Hepatocellular carcinoma (HCC) is a prevalent and heterogeneous tumor with limited treatment options and unfavorable prognosis. The crucial role of a…

Date: 2024-09-13

Multivalent MVA-vectored vaccine elicits EBV neutralizing antibodies in rhesus macaques that reduce EBV infection in humanized mice

Abstract: Introduction: Epstein-Barr virus (EBV) is an oncogenic human herpesvirus associated with ~350,000 cases of lymphoid and epithelial malignancies every year, and is…

Date: 2024-09-13

Establishing a risk stratification model to identify clinically high-risk N0 breast cancer who could benefit from regional nodal irradiation: a single institute analysis

Abstract: Background: The purpose of this real-world study was to investigate the risk factors for developing recurrence among patients with pathological T1-3N0 breast cancer (BC)…

Date: 2024-09-13

Integrating genomic profiling to clinical data: assessing the impact of CD147 expression on plaque stability

Abstract: Background: Acute Coronary Syndrome (ACS) continues to be a leading cause of death and illness worldwide. Differentiating stable from unstable coronary plaques is…

Date: 2024-09-13

Causality between sarcopenia and diabetic neuropathy

Abstract: Background: Past studies have demonstrated that diabetic neuropathy is related to sarcopenia, but the further causal relation is still unclear. We sought to investigate…

Date: 2024-09-13

Association between serum iron status and the risk of five bone and joint-related diseases: a Mendelian randomization analysis

Abstract: Background: According to reports, iron status has been associated with the risk of bone and joint-related diseases. However, the exact role of iron status in the…

Date: 2024-09-13

Poor prognostic factors for relapse of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies after combination therapy

Abstract: Introduction: This study aimed to identify useful clinical indicators for predicting the relapse of interstitial lung disease (ILD) complicated with anti-aminoacyl-tRNA…

Date: 2024-09-13