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Synergistically improved cardiovascular outcomes in type 2 diabetes mellitus patients with combined treatment of SGLT-2 inhibitors and pioglitazone

Abstract: Background: Sodium-glucose co-transporter-2 inhibitors (SGLT2i) have cardiovascular (CV) benefits, particularly in reducing the risk of heart failure (HF). Pioglitazone…

Date: 2024-08-30

GH receptor polymorphisms guide second-line therapies to prevent acromegaly skeletal fragility: preliminary results of a pilot study

Abstract: Background: Skeletal fragility is characterized by increased frequency of vertebral fractures (VFs) in acromegaly. Several trials were conducted to identify modifiable…

Date: 2024-08-30

Association between serum transferrin saturation levels and heart failure in adults aged ?40 years: a cross-sectional study based on NHANES (2017-2020.03)

Abstract: Background: Limited data are available regarding the association between serum transferrin saturation (TSAT) levels and heart failure (HF).

Date: 2024-08-30

Health condition and socioeconomic status mediate the causal effect of reproductive traits on nonalcoholic fatty liver disease: evidence from Mendelian randomization study

Abstract: Background: Observational data posits a correlation between reproductive traits and nonalcoholic fatty liver disease (NAFLD), but their causal inference is still…

Date: 2024-08-30

Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model

Abstract: Background: Limited availability and side effects of opioids have led to an increased use of non-opioid analgesia in animal disease models. However, by affecting the…

Date: 2024-08-30

Comparison of electrocardiogram parameters and echocardiographic response between distinct left bundle branch area pacing modes in heart failure patients

Abstract: Background: Left bundle branch area pacing (LBBAP) has become an alternative method for cardiac resynchronization therapy. Various modes of LBBAP have been determined,…

Date: 2024-08-29