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Native C3 is activated without proteolytic cleavage by transformation to C3(H 2 O) on phospholipid-scrambled cell membranes

Abstract: Tick-over of C3 to fluid-phase C3(H 2 O) is considered the initiator of the alternative pathway by mediating random depositing of C3b on target surfaces. This slow…

Date: 2025-12-16

Temporal modulation of gene expression in a controlled Schistosoma mansoni human infection model

Abstract: Schistosomiasis is caused by parasitic blood flukes of the genus Schistosoma . Despite ongoing mass drug administration efforts, the disease remains a major public…

Date: 2025-12-16

CCL18: a potential immunosuppressive biomarker for prognosis in ABC diffuse large B-cell lymphoma

Abstract: Activated B-cell (ABC) diffuse large B-cell lymphoma (DLBCL) has worse outcomes than the germinal center B-cell (GCB) subtype, but underlying molecular mechanisms remain…

Date: 2025-12-15

Blood bank trends in Kuwait: five-year analysis of donations and investigations

Abstract: Reliable national transfusion services require continuous surveillance of donation activity, inventory losses, transfusion-transmissible infection (TTI) screening, and…

Date: 2025-12-15

Data-driven cluster analysis and external validation identify phenotypic subgroups in renin-independent aldosteronism with differential cardiovascular risk and therapeutic implications

Abstract: Renin-independent aldosterone secretion contributes to aldosteronism and heightened cardiovascular risk, but renin-independent aldosteronism is highly heterogenous. A…

Date: 2025-12-15

Real-world glycemic outcomes of a tubeless automated insulin delivery system: a single-center observational study in Italy

Abstract: The objective of this study is to describe the short-term change observed in CGM-related measures and relevant clinical variables in individuals with type 1 diabetes…

Date: 2025-12-15

The CHANSE score: a novel clinical tool incorporating the heel drop test for the diagnosis of pediatric appendicitis

Abstract: Acute appendicitis is one of the most common abdominal surgical emergencies in children presenting to the emergency department. Although clinical guidelines emphasize…

Date: 2025-12-15

Analysis of clinical characteristics and risk factors of infectious mononucleosis in children with splenomegaly

Abstract: The initial Epstein–Barr virus infection in children often presents as infectious mononucleosis (IM). However, the risk factors for splenomegaly in IM remain unclear.…

Date: 2025-12-15

Vitamin D deficiency and asthma morbidity in school-age children: a single-center cohort study

Abstract: Asthma remains a major cause of morbidity among school-age children worldwide, with deficiency of vitamin D increasingly recognized as a modifiable factor influencing…

Date: 2025-12-15

Anoscrotal distance and urogenital anomalies in ART-conceived male infants: a retrospective cohort study

Abstract: Assisted reproductive technology (ART) is widely used, yet potential effects on androgen-sensitive male genital development remain a concern. Anoscrotal distance (ASD),…

Date: 2025-12-15