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Initial experience of spatially fractionated lattice radiation therapy for palliative treatment of pediatric bulky tumors

Abstract: Spatially fractionated radiation therapy (SFRT) has demonstrated high clinical response rates with minimal toxicity in adult patients with bulky tumors, including…

Date: 2025-10-27

An early-stage 3D fibroblast-featured tumor model mimics the gene expression of the naïve tumor microenvironment, including genes involved in cancer progression and drug resistance

Abstract: The tumor microenvironment (TME) plays a crucial role in cancer progression, yet the interactions between tumor cells and stromal components, such as fibroblasts, remain…

Date: 2025-10-27

Preoperative absolute neutrophil count: a potential indicator for prognosis in carcinoembryonic antigen normal stage I non-small cell lung cancer

Abstract: Carcinoembryonic antigen (CEA) is still the most valuable tumor marker in the diagnosis and prognosis of non-small cell lung cancer (NSCLC) patients; however, its…

Date: 2025-10-27

Dose response test of patient-derived cancer organoids to irradiation

Abstract: Patient-derived cancer organoids emerged as an innovative model in basic and translational medicine research, as well as precision medicine. However, most radiation…

Date: 2025-10-27

Effects of menopausal hormone therapy on gut microbiota in postmenopausal women and the relationship with bone metabolism

Abstract: Menopausal Hormone Replacement Therapy (MHT) is widely used by peri- and post-menopausal women to alleviate menopause-related symptoms and preventing bone loss, but the…

Date: 2025-10-27

Analysis of risk factors and development of a prediction model for long-term prognosis in patients with ischemic heart failure after percutaneous coronary intervention

Abstract: This study aimed to investigate the factors influencing the long-term prognosis of patients with ischemic heart failure (IHF) after percutaneous coronary intervention…

Date: 2025-10-27

Differential expression of platelet CD147 in moderate altitude conditions: implications for coronary plaque stability assessment

Abstract: As a major contributor to global death rates, coronary heart disease (CHD) remains critical. This investigation examines CD147's utility for assessing plaque…

Date: 2025-10-27

Establishment of prognostic signature based on neutrophil extracellular traps-related genes in acute myeloid leukemia: a bioinformatics analysis

Abstract: Acute myeloid leukemia (AML) is a hematological malignancy with a high incidence of febrile neutropenia during the first two treatment cycles. This study aims to develop…

Date: 2025-10-24

Sleep quality during preparation for RAI: recombinant TSH vs. levothyroxine withdrawal

Abstract: Patients with differentiated thyroid cancer (DTC) suffer from impaired sleep quality, which may be further impaired after radioactive iodine (RAI) treatment. The…

Date: 2025-10-24

Interplay of endocrine and psychological factors in IVF/ICSI outcomes: a prospective cohort analysis

Abstract: Infertility poses considerable challenges to both the endocrine system and psychological well-being of affected women. In particular, those undergoing Assisted…

Date: 2025-10-24