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Real-world safety profile of sonidegib: a disproportionality analysis based on the FDA adverse event reporting system

Abstract: Sonidegib is a novel treatment for locally advanced basal cell carcinoma (LaBCC) with demonstrated efficacy and safety in clinical trials. However, its real-world safety…

Date: 2025-10-23

Improving diagnostic interpretability of abdominal ultrasound for neonates with suspected intestinal injury

Abstract: Abdominal ultrasound (AUS) is increasingly utilized as a diagnostic adjunct in neonates undergoing evaluation for intestinal injuries such as necrotizing enterocolitis…

Date: 2025-10-23

Rising trends in the burden of migraine among children and adolescents: a comprehensive analysis from 1990 to 2021 with future predictions

Abstract: Migraine is a leading neurological disorder among children and adolescents. Its high prevalence and risk of chronic progression significantly reduce quality of life and…

Date: 2025-10-23

Integrated bioinformatic analysis and machine learning developed a prognostic model based on mitochondrial function for acute myeloid leukemia

Abstract: The disease burden of acute myeloid leukemia (AML) continues to pose a significant public health challenge globally. Mitochondria play a critical role in tumor…

Date: 2025-10-23

Association between preoperative albumin and postoperative pneumonia in patients undergoing major non-cardiac surgery

Abstract: Postoperative pneumonia is a common and serious complication following non-cardiac surgery. However, the relationship between preoperative albumin levels and…

Date: 2025-10-23

Short stays, high needs: gender disparities in Czech forensic psychiatric inpatient care

Abstract: Limited research has explored the sociodemographic profiles, institutional behaviours, and treatment needs of women receiving forensic psychiatric care, particularly in…

Date: 2025-10-23

Serum zonulin, brain-derived neurotrophic factor, and oxidative stress levels in individuals using paper (A4) impregnated with synthetic cannabinoids

Abstract: A4 is paper impregnated with synthetic cannabinoids, used as a novel psychoactive substance. The aim of this study was to investigate serum zonulin, brain-derived…

Date: 2025-10-23

Dietary changes as a risk factor and remedy for meditation-related challenges

Abstract: Recent research has documented a range of challenging, distressing, or impairing experiences that can result from Buddhist meditation practices (Lindahl et al.). The…

Date: 2025-10-23

Simultaneous bilateral intravitreal anti-vascular endothelial growth factor injections from one vial for diabetic macular edema: a retrospective analysis

Abstract: The objective of this study was to assess the safety and efficacy of simultaneous bilateral intravitreal injections of anti-vascular endothelial growth factors…

Date: 2025-10-23

Global burden of age-related macular degeneration (1990–2021): trends, age-sex disparities, and socioeconomic dynamics from the GBD study

Abstract: This study aimed to assess the global burden of Age-related macular degeneration (AMD) across countries, regions, and age groups by sex, sociodemographic index (SDI)…

Date: 2025-10-23