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Relationship between frailty and depressive symptoms in older adults: role of activities of daily living and sleep duration

Abstract: Introduction: Previous studies have demonstrated that frailty is associated with depressive symptoms among older people and significantly increase the risk of difficulty…

Date: 2024-06-26

Multiple immune-related adverse events secondary to checkpoint inhibitor therapy in patients with advanced cancer: association with treatment effectiveness

Abstract: Introduction: Checkpoint inhibitors (CPI) are widely used in cancer treatment with a potential of causing immune-related adverse events (IRAEs). Several studies have…

Date: 2024-06-26

Deciphering the molecular landscape of rheumatoid arthritis offers new insights into the stratified treatment for the condition

Abstract: Background: For Rheumatoid Arthritis (RA), a long-term chronic illness, it is essential to identify and describe patient subtypes with comparable goal status and…

Date: 2024-06-25

Association of increased participation in social activity in later life with risk of all-cause mortality and heart diseases in older people: results from the Chinese Longitudinal Healthy Longevity Survey (CLHLS)

Abstract: Background: Previous studies have shown social activity is associated with reduced risk of health outcomes. However, among older people (?65?years) who were socially…

Date: 2024-06-25

Amorphous calcium carbonate as a novel potential treatment for osteoarthritis in dogs: a pilot clinical study

Abstract: Background: Amorphous calcium carbonate (ACC) is a potential new treatment for canine osteoarthritis (OA) with novel mechanisms based on local pH modulation and…

Date: 2024-06-25

Multi-omic validation of the cuproptosis-sphingolipid metabolism network: modulating the immune landscape in osteosarcoma

Abstract: Background: The current understanding of the mechanisms by which metal ion metabolism promotes the progression and drug resistance of osteosarcoma remains incomplete.…

Date: 2024-06-25

Baseline monocyte count predicts symptom improvement during intravenous ketamine therapy in treatment-resistant depression: a single-arm open-label observational study

Abstract: Background: Neuroinflammatory processes in depression are associated with treatment resistance to conventional antidepressants. Ketamine is an effective new therapeutic…

Date: 2024-06-24

Sensory Phenomenon Assessment Scale: a new tool for assessment of tic-associated sensations

Abstract: Background: Sensory symptoms linked to tic disorder (TD) are challenging to quantify via self- or parent-reported measures. The current study aimed to develop a novel…

Date: 2024-06-24

Serine racemase deletion alters adolescent social behavior and whole-brain cFos activation

Abstract: Background: Neurodevelopmental disorders (NDDs) can cause debilitating impairments in social cognition and aberrant functional connectivity in large-scale brain…

Date: 2024-06-24