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Prevalence of tobacco smoking and its association with disease severity and psoriatic arthritis among patients with nail psoriasis in China: a cross-sectional study

Abstract: Nail psoriasis is a common, treatment-refractory manifestation of psoriasis. Smoking is a key environmental factor implicated in nail and articular psoriasis. While…

Date: 2025-12-09

Using mass cytometry to probe the STAT signaling landscape in circulating immune cells in Rheumatoid Arthritis uncovers signaling dysregulation and correlation with disease activity

Abstract: The phosphorylation state of signaling proteins is a useful measure of cell function. The high dimensionality of mass cytometry (CyTOF) allows assessment of a large…

Date: 2025-12-09

Compound sulfamethoxazole for pediatric pertussis: a retrospective cohort study in a region with high macrolide resistance

Abstract: In recent years, the incidence of pertussis has been increasing globally. The high prevalence of macrolide-resistant strains has led to a significant rise in both…

Date: 2025-12-09

An individualized risk prediction tool for ectopic pregnancy within the first 10?weeks of gestation based on machine learning algorithms

Abstract: As the main cause of maternal deaths in early pregnancy, delayed diagnosis of ectopic pregnancy (EP) may lead to severe consequences. Patients with pregnancy of unknown…

Date: 2025-12-09

The application of blended learning in obstetrics teaching: a comprehensive teaching model integrating an intelligent, interactive induction platform

Abstract: Hybrid learning, integrating diverse teaching methods and resources, is promising in education. In nursing, it suits varied learning styles via multiple channels and…

Date: 2025-12-09

The effect of remimazolam versus conventional anesthesia on postoperative delirium in frail patients: a prospective, controlled cohort study

Abstract: Frail elderly patients are at high risk for postoperative delirium (POD), a serious complication associated with poor outcomes. The choice of anesthetic agent may…

Date: 2025-12-09

Analysis of effectiveness and safety of cisatracurium infusion during laparoscopic abdominal surgery

Abstract: To explore the efficacy and safety of different infusion modes of cisatracurium in laparoscopic abdominal surgery. In this randomized controlled trial, 90 patients…

Date: 2025-12-09

The microbiome exists in the neuroretina and choroid in normal conditions and responds rapidly to retinal injury

Abstract: To investigate the microbial profiles in the retina and RPE/choroid, and how they respond to retinal injury. Adult C57BL/6J mice were subjected to retinal laser burns…

Date: 2025-12-09

Effects of bolus injection rate on the pharmacodynamics and pharmacokinetics of propofol, etomidate and sufentanil in rats

Abstract: The preclinical phase of innovative drug research and development involves a comprehensive assessment of multiple variables that may influence therapeutic outcomes and…

Date: 2025-12-08

Effect of sevoflurane post-conditioning on postoperative cognitive function in carotid endarterectomy patients: a randomized, double-blind, controlled trial

Abstract: This study evaluated the effect of low-dose sevoflurane post-conditioning on early neurocognitive recovery in patients aged 50–80?years undergoing carotid endarterectomy…

Date: 2025-12-08