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Fruquintinib saddles tumor immune tolerance by curbing pro-tumoral immature myeloid cell populations

Abstract: Myeloid-derived cells, particularly immature populations and tumor-associated macrophages, play a pivotal role in establishing immune tolerance and suppressing antitumor…

Date: 2025-12-11

Emotional intelligence and clinical decision-making confidence in nurses: the chain mediating effect of creative self-efficacy and self-directed learning

Abstract: Clinical decision-making competence underpins autonomous nursing practice. While external influences are documented, context-dependent psychological mechanisms linking…

Date: 2025-12-10

The actual experiences of nurses’ in implementing hypothermia prevention practices during post-anesthesia care unit: a qualitative study based on the PRECEDE-PROCEED model

Abstract: Hypothermia is one of the most common postoperative complications in the post-anesthesia care unit (PACU), and preventive measures are crucial for improving patient…

Date: 2025-12-10

Association between iron deficiency anemia and risk of hearing loss among female patients: a multi-institutional cohort study

Abstract: Iron deficiency anemia (IDA) represents the most prevalent nutritional deficiency worldwide, disproportionately affecting women of reproductive age. Emerging evidence…

Date: 2025-12-10

Preoperative insomnia exacerbates postoperative sleep fragmentation in elderly arthroplasty patients: a prospective cohort study

Abstract: Preoperative insomnia is prevalent among elderly arthroplasty patients, yet its impact on postoperative sleep disturbance (PSD) remains underexplored. This study…

Date: 2025-12-10

RPL41 inhibits the proliferation and migration of retinoblastoma through the ARL5B-associated lysosomal trafficking

Abstract: Retinoblastoma is the most common intraocular cancer in infants and children, with a significant potential for metastasis. The mini-peptide ribosomal protein L41 (RPL41)…

Date: 2025-12-10

Alterations in the composition of meibomian gland secretions in patients with meibomian gland dysfunction based on Raman spectroscopy

Abstract: To investigate biochemical alterations in meibum from patients with obstructive meibomian gland dysfunction (MGD) using Raman spectroscopy, with a focus on lipid…

Date: 2025-12-10

Therapeutic keratopigmentation Vis-à-Vis in blind eyes: complications and outcomes in a series of 184 eyes

Abstract: To evaluate the outcomes, complications, and patient satisfaction following therapeutic keratopigmentation Vis-à-Vis in blind eyes. This retrospective case series…

Date: 2025-12-10

No retinopathy after orbital irradiation in patients with thyroid eye disease – a follow up study

Abstract: Thyroid eye disease (TED) is an autoimmune disease of the orbit. In moderate to severe active disease, orbital radiotherapy (ORT) is a treatment option. Diabetes is…

Date: 2025-12-10

Metformin improves pregnancy outcomes in non-PCOS women with insulin resistance and recurrent implantation failure before frozen embryo transfer

Abstract: Recurrent implantation failure (RIF) leads to a significant waste of embryos and imposes substantial physical, emotional, and financial stress on patients. Given its…

Date: 2025-12-10