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Increased propofol consumption with later anesthesia start times in sedated gastrointestinal endoscopy: insights from regression and machine learning models

Abstract: Chronopharmacology is an important but underexplored aspect of propofol administration. Despite the implementation of propofol administration models, none have yet…

Date: 2025-10-21

“We cannot live like Canadian”: Yazidi refugees’ perspectives on mental health, coping strategies and barriers to care

Abstract: The Yazidi people are a Kurdish religious minority group who have been persecuted by the Islamic State of Iraq and Syria (ISIS). The complexity of the trauma the Yazidi…

Date: 2025-10-21

Gender differences in the association between smoking and the risk of suicide in depressed patients: a longitudinal national cohort study

Abstract: Although the gender differences in suicide and smoking are well-known, studies exploring the impact of gender on the relationship between smoking and suicide are…

Date: 2025-10-21

Comparative efficacy of intravitreal aflibercept biosimilar QL1207 versus reference aflibercept in the treatment of diabetic macular edema

Abstract: This study aims to comparatively evaluate the clinical efficacy of intravitreal injections of aflibercept biosimilar QL1207 and the reference aflibercept in the…

Date: 2025-10-21

The ProCVT smart-sheet as a new screening tool for cardiovascular autonomic neuropathy: a feasibility study

Abstract: Cardiovascular autonomic neuropathy (CAN) is a severe complication of diabetes that impairs the regulation of the cardiovascular system. This can cause hemodynamic…

Date: 2025-10-21

Low-dose vs. standard-dose alteplase for acute ischemic stroke: a real-world single-center retrospective study

Abstract: To investigate the real-world usage patterns and clinical outcomes of low-dose (0.6?mg/kg) versus standard-dose (0.9?mg/kg) intravenous alteplase in patients with acute…

Date: 2025-10-21

Predictors of unplanned hospital readmissions and emergency department revisits in patients with acute ischemic stroke

Abstract: We aim to identify factors associated with emergency department (ED) revisits and hospital readmissions after acute ischemic stroke (AIS) diagnosis and to determine if…

Date: 2025-10-21

Interpretable machine learning for predicting early neurological deterioration in symptomatic intracranial atherosclerotic stenosis

Abstract: To develop and validate a machine learning (ML) model for early neurological deterioration (END) risk prediction in patients with symptomatic intracranial…

Date: 2025-10-21

Edaravone Dexborneol in acute ischemic stroke patients treated with combined intravenous thrombolysis and mechanical thrombectomy for large vessel occlusion

Abstract: Mechanical thrombectomy (MT), when combined with intravenous thrombolysis (IVT), has emerged as an effective therapeutic strategy for acute ischemic stroke (AIS).…

Date: 2025-10-21

Efficacy and safety of intravenous tenecteplase thrombolysis in diffusion-weighted imaging-negative posterior circulation ischemic stroke

Abstract: Clear evidence supporting thrombolytic therapy in diffusion-weighted imaging (DWI)-negative posterior circulation ischemic stroke (PCIS) is lacking. We aimed to…

Date: 2025-10-21