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Colonoscopy outcomes of primary screening negative participants highlight the missed diagnosis problem of colorectal cancer screening: an observational study from Yuexiu district in Guangzhou, China

Abstract: False negatives in colorectal cancer (CRC) screening remained a widespread concern, particularly given the notable incidence of false negative results from fecal…

Date: 2025-10-21

Establishment and comparison of three fear of progression risk prediction models for gynecological malignancies patients based on machine learning

Abstract: This study applied the Society Ecosystems Theory to investigate Fear of Progression (FoP) prevalence and predictors in gynecological malignancy patients. By constructing…

Date: 2025-10-21

Comparison of adverse events between intensity-modulated radiation therapy and tomotherapy for early stage breast cancer: a retrospective cohort study

Abstract: Early stage breast cancer treated with adjuvant radiotherapy with two different techniques, tomotherapy (TOMO) and intensity-modulated radiation therapy (IMRT), and…

Date: 2025-10-21

MFSD12 promotes proliferation, metastasis and invasion of hepatocellular carcinoma cells and its potential correlation with HAVCR2/LGALS9 immune checkpoint axis

Abstract: Major Facilitator Superfamily Domain-containing 12 (MFSD12) has emerged as a critical transmembrane protein with increasingly recognized roles in various cancers. The…

Date: 2025-10-21

Prognostic value of patient-reported outcomes for survival in patients with advanced lung cancer receiving immune checkpoint inhibitors

Abstract: There is potential clinical utility in using patient-reported outcomes (PROs) to predict survival in patients with advanced non-small cell lung cancer. We assessed the…

Date: 2025-10-21

The 41BB-agonist potentiates the therapeutic efficacy of a combined irreversible electroporation ablation treatment of lung cancer by promoting unexpected CD8 + CD103 + cDC1 and tissue-resident memory T cell responses

Abstract: Irreversible electroporation (IRE) is a relatively new, non-thermal ablation technology for cancer treatment that requires further investigation to optimize its…

Date: 2025-10-21

Global, regional, and national epidemiology and risk factors of geriatric digestive system cancers from 1990 to 2021

Abstract: Using Global Burden of Disease (GBD) 2021 data, we analyzed incidence, mortality, disability-adjusted life years (DALYs), and risk factors for six geriatric digestive…

Date: 2025-10-21

Predicting breast cancer treatment response and prognosis using AI-based image classification

Abstract: Accurate prediction of treatment response and prognosis in breast cancer patients is critical to advance personalized medicine and optimize therapeutic decision-making.…

Date: 2025-10-21

Hsp70 regulates CD24 expression and promotes metastasis and invasion of lung cancer via the MAPK/ERK signaling pathway

Abstract: To investigate the effects and mechanisms of Hsp70-mediated regulation of CD24 expression on the invasion and metastasis of lung cancer. Protein-protein interactions…

Date: 2025-10-21

Recognition of the novel items for prediction of bone metastasis in colorectal cancer

Abstract: To explore whether uric acid (UR), neutrophil/lymphocyte ratio (NLR) and uric acid/albumin ratio (UAR) can predict bone metastasis in colorectal cancer (CRC). A…

Date: 2025-10-21