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Primary care and specialist physicians’ prescribing preferences for concurrent probiotic-antibiotic therapy: a multinational clinical practice survey across 13 countries

Abstract: Antibiotic-induced intestinal microbiota disruption represents a significant clinical concern, yet physician practices regarding concurrent probiotic supplementation…

Date: 2025-10-17

Analysis of the twelve cases of immune-related myocarditis caused by cadonilimab

Abstract: This study aims to analyze the clinical characteristics of immune-related myocarditis caused by cadonilimab, thereby providing a reference for its safe clinical…

Date: 2025-10-17

Healthcare costs of cutaneous melanoma according to comorbidity patterns: a population-based study from the Regional Cancer Registry of the Veneto Region

Abstract: Cutaneous malignant melanoma represents a notable public health issue, characterized by a rapidly increasing incidence, particularly among younger populations. Despite…

Date: 2025-10-17

Proteins linked to type II interferon response in Sjögren’s disease: novel indicators for disease monitoring and predicting treatment response to leflunomide and hydroxychloroquine combination therapy

Abstract: To identify biomarkers and endotypes predictive of treatment response, monitor disease activity, and explore pathways associated with the clinical efficacy of…

Date: 2025-10-17

Marked under-diagnosis of Lambert-Eaton myasthenic syndrome in small cell lung cancer: an analysis of real-world claims data

Abstract: Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune neurologic condition causing progressive muscle weakness that can occur as a paraneoplastic disorder, most…

Date: 2025-10-17

Co-occurrence patterns of esophageal and stomach cancer across 204 countries and territories: a spatial correspondence and systematic analysis

Abstract: Esophageal and gastric cancers are common malignant tumors of the digestive tract worldwide, characterized by a substantial disease burden and significant regional…

Date: 2025-10-17

Development and validation of an interpretable machine learning model for acute radiation dermatitis in breast cancer

Abstract: Radiation dermatitis (RD), a common adverse reaction in breast cancer radiotherapy, impairs quality of life and increases healthcare burdens. Developing an effective…

Date: 2025-10-17

Correlation of immune cell subsets in the tumor microenvironment and peripheral blood with immunotherapy response in esophageal squamous cell carcinoma

Abstract: Esophageal squamous cell carcinoma (ESCC) is commonly diagnosed at an advanced stage, where conventional chemoradiotherapy offers only limited clinical benefit. Immune…

Date: 2025-10-17

Machine learning model for predicting epidermal growth factor receptor expression status in breast cancer using ultrasound radiomics

Abstract: The epidermal growth factor receptor (EGFR) is a clinically important target, as its expression in patients with breast cancer influences both overall and disease-free…

Date: 2025-10-17

Modest radiation dose escalation for early-stage anal cancer: cancer control and toxicity outcomes

Abstract: The optimal dose for patients with early-stage squamous cell carcinoma of the anus (SCCA) is unknown. We aimed to evaluate the impact of modest dose escalation (54 Gray…

Date: 2025-10-17