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Transcriptomic profiling of diabetic retinopathy: insights into RPL11 and bisphenol A

Abstract: Diabetic retinopathy (DR) is a leading microvascular complication of diabetes mellitus, causing irreversible vision loss in adults worldwide. However, the molecular…

Date: 2025-11-26

Impact of pre-operative cervical spine function on post-operative functional rehabilitation in patients after laminoplasty

Abstract: Laminoplasty has been widely used for the treatment of multilevel degenerative cervical myelopathy (DCM). However, patients often experience persistent axial symptoms,…

Date: 2025-11-26

Optimizing surgical strategies for subaxial cervical fracture-dislocation: a facet and disc injury-based approach

Abstract: To investigate the influence of facet joint and intervertebral disc injuries on surgical approach selection in subaxial cervical fracture-dislocation. We retrospectively…

Date: 2025-11-26

Association study between intestinal microbiota dysbiosis in inflammatory bowel disease and the global disease burden growth trend

Abstract: Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is a group of chronic intestinal inflammatory diseases. Its incidence and prevalence…

Date: 2025-11-26

Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis

Abstract: Evidence suggested that capsaicin may protect against steatotic liver disease (SLD), but these findings lack validation in population-based studies. This research aimed…

Date: 2025-11-26

Epilepsy-associated CHD2 missense variants and optimization strategies for genetic diagnosis: a comparative analysis of algorithms

Abstract: The CHD2 gene is one of the most common causative genes of developmental and epileptic encephalopathy (DEE). With the advent of high-throughput sequencing, identifying…

Date: 2025-11-26

Videonystagmography features and clinical symptoms correlate with Parkinson's clinical subtypes

Abstract: Analyzing the differences in video-nystagmography (VNG) parameters among Parkinson's disease (PD) patients with distinct motor subtypes and evaluate the correlation…

Date: 2025-11-26

Administration of eptifibatide as rescue therapy during mechanical thrombectomy in acute ischemic stroke

Abstract: The success of the technical implementation of mechanical thrombectomy (MT) depends on many factors. Considering the experience of the interventional radiologist and the…

Date: 2025-11-26

SAFE-CGRP study: multicenter retrospective evaluation of the safety of CGRP pathway–targeting monoclonal antibodies in migraine with relevant comorbidities or conditions excluded from trials

Abstract: Monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP) have shown efficacy in the treatment of migraine. However, certain comorbidities have been…

Date: 2025-11-26

Single-cell transcriptomics identifies FOSL1-regulated IGFBP3+ melanoma subtype as a neuro-immunoregulatory signaling hub facilitating tumor progression

Abstract: The most aggressive type of skin cancer, melanoma, has a high prevalence of metastases and a poor prognosis. Despite advancements in treatment, drug resistance and tumor…

Date: 2025-11-26