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Establishment of a nomogram model to predict malignant risk in patients with ocular surface squamous neoplasia and ocular surface squamous epithelial tumors

Abstract: To develop and internally validate a nomogram to predict the probability that a clinically suspected ocular surface squamous epithelial tumor is histopathologically…

Date: 2025-11-25

Interpretable machine learning model for predicting covert hepatic encephalopathy in patients with cirrhosis: a multicenter study

Abstract: Covert hepatic encephalopathy (CHE) is a neurocognitive complication affecting 40.9–50.4% of patients with cirrhosis. It often remains undiagnosed owing to its…

Date: 2025-11-25

Immune responses in pulmonary sarcoidosis following COVID-19

Abstract: The complex interplay between sarcoidosis and COVID-19 remains an important area of research, since COVID-19 leads to long-term changes in the immune system. However,…

Date: 2025-11-25

Anti-HER2/neu TCR-T Cells in Action: linking transcriptional signatures, secretomics, and In Vivo tumor suppression

Abstract: T cell receptor-engineered T cell therapy has emerged as a promising approach in cancer immunotherapy, leveraging the ability of T cells to recognize tumor antigens…

Date: 2025-11-25

IgA expressed by glomerular mesangial cells is involved in the pathogenesis of IgA nephropathy

Abstract: The widely accepted “multi-hit hypothesis” of IgAN pathogenesis was challenged, as efficient depletion of CD20+ B cells failed to reduce serum galactose-deficient IgA1…

Date: 2025-11-25

Temporal trends and global burden of urolithiasis: a comparative analysis of incidence, prevalence, mortality, and disability-adjusted life years in China and globally from 1990 to 2021

Abstract: Urolithiasis significantly affects global health, contributing to substantial morbidity, healthcare costs, and reduced quality of life. Understanding temporal changes in…

Date: 2025-11-24

Plasma corin levels provide minimal prognostic utility in left atrial reverse remodeling after catheter ablation of atrial fibrillation: an observational study

Abstract: This study aims to assess the impact of plasma corin levels on left atrial reverse remodeling (LARR) in patients with atrial fibrillation (AF) after catheter ablation…

Date: 2025-11-24

Association between triglyceride glucose-body mass index and long-term adverse outcomes in individuals with heart failure: a retrospective cohort study

Abstract: Insulin resistance (IR) plays a pivotal role in the pathogenesis and progression of heart failure (HF), and may be exacerbated in advanced stages of HF, thereby…

Date: 2025-11-24

The oncometabolite R-2-hydroxyglutarate inhibits microglial activation via the FTO/NF-?B pathway

Abstract: Mutations in isocitrate dehydrogenase 1 (mIDH1) generate the oncometabolite (R)-2-hydroxyglutarate (R-2HG), which promotes tumorigenesis by inhibiting…

Date: 2025-11-24

Time series forecasting of red blood cell demand in hematology patients using SARIMA and exponential smoothing models: a retrospective analysis in a Chinese tertiary hospital

Abstract: Red blood cells (RBCs) infusion is very important for the treatment of hematology patients, but how to maintain a balanced state between the supply and demand of RBCs is…

Date: 2025-11-24