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A model structure for describing uncertainties in benefit-risk assessment of oncology drug applications

Abstract: The European Medicines Agency (EMA) uses structured reports to communicate the scientific review of drug applications. A European Public Assessment Report (EPAR) is…

Date: 2025-10-15

Interpretable machine-learning-based prediction of postpartum haemorrhage in normal vaginal births in Shanghai, China

Abstract: Postpartum haemorrhage is the most common complication associated with vaginal birth and a principal cause of maternal mortality. While clinical guidelines suggest that…

Date: 2025-10-15

Global burden of early-onset pancreatic cancer attributable to metabolic risks from 1990 to 2021, and projections to 2030

Abstract: This study, based on the Global Burden of Disease (GBD) 2021 data, systematically analyzed the changes in the disease burden of early-onset pancreatic cancer (EOPC)…

Date: 2025-10-15

Metabolic syndrome worsens sarcopenia and reduces nutritional therapy benefits in advanced gastric cancer

Abstract: Emerging evidence suggests metabolic syndrome (MetS) exacerbates sarcopenia progression and compromises nutritional interventions, yet its dual role as both etiological…

Date: 2025-10-15

Global, regional, and national differences in the incidence and mortality of digestive congenital anomalies from 1990 to 2021, with projections for future trends

Abstract: Digestive congenital anomalies (DCA) remain a major yet unevenly distributed cause of death and disability worldwide. We aimed to quantify global, regional, and national…

Date: 2025-10-14

Propensity score matching analysis of the relationship between allogeneic blood transfusion and postoperative pulmonary complications in scoliosis correction surgery: a retrospective study

Abstract: Surgery is still the treatment of choice for patients with moderate to severe scoliosis, and vertebral column resection can significantly correct scoliosis. However,…

Date: 2025-10-14

Examination of the effect of spinal anesthesia informational video on anxiety level and postoperative analgesia in transurethral resection of prostate

Abstract: To evaluate the effect of an informational video on spinal anesthesia in reducing preoperative anxiety and postoperative analgesic requirements in patients undergoing…

Date: 2025-10-14

Depression and somatization in Turkish migrants in Germany: the role of migration-related stressors

Abstract: Migration-related stressors (MRS), such as loss, cultural conflict, and language barriers, are linked to increased psychological distress. This study investigates the…

Date: 2025-10-14

Augmenting early stroke diagnosis with an eye-tracker

Abstract: Posterior circulation stroke (PCS) presents significant diagnostic challenges due to poorly localizing and non-specific symptoms, such as dizziness, nausea, and…

Date: 2025-10-14

Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells

Abstract: Radioresistance results in relapse and treatment failure in locally advanced colorectal cancer (CRC) patients. HMGB1 is reportedly associated with radioresistance in…

Date: 2025-10-14