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Somatic gene variation profiles in geriatric and adult malignant melanoma patients

Abstract: Skin cancer is a highly heterogeneous disease affecting substantial geriatric individuals. Therefore, understanding gene variants and their presence in geriatric and…

Date: 2025-10-10

Treatment experience in managing severe immune-mediated hepatotoxicity induced by immune checkpoint inhibitors

Abstract: Although multiple guidelines for managing severe immune-mediated hepatotoxicity (IMH) induced by immune checkpoint inhibitors (ICIs) were recommended, real-world…

Date: 2025-10-10

Temporal trends in cancer mortality attributable to high BMI in Asia: an age-period-cohort analysis based on GBD 1992–2021

Abstract: High body mass index (BMI) is a well-established modifiable risk factor for cancer. This study aims to assess temporal trends and contributing factors in cancer…

Date: 2025-10-10

Minimally invasive versus open surgery in uterine serous carcinoma: impact on recurrence and survival in a multicenter cohort

Abstract: Uterine serous carcinoma (USC) is a highly aggressive subtype of endometrial cancer, characterized by high recurrence rates and poor prognosis. While minimally invasive…

Date: 2025-10-10

Prevalence of malnutrition and appropriateness of nutritional support in hospitalized patients: a GLIM-based study

Abstract: To investigate the current status of nutritional risk, malnutrition, and nutritional therapy among hospitalized patients in Hunan Province, in order to provide evidence…

Date: 2025-10-10

Prognostic genes related to mitochondrial dynamics and mitophagy in diffuse large B-cell lymphoma are identified and validated using an integrated analysis of bulk and single-cell RNA sequencing

Abstract: While the link between mitochondrial homeostasis, specifically dynamics and mitophagy, and the progression of diffuse large B-cell lymphoma (DLBCL) has been suggested,…

Date: 2025-10-09

On-treatment modified Glasgow Prognostic Score (mGPS) in hepatocellular carcinoma treated with atezolizumab and bevacizumab provides prognostic information

Abstract: Hepatocellular carcinoma (HCC) is associated with high cancer-specific mortality. While immune-checkpoint inhibitors (ICIs) improved overall survival (OS) compared to…

Date: 2025-10-09

Pseudolaric acid B induces G2/M phase arrest in canine mammary tumor cells by targeting CDK1

Abstract: Current management of canine mammary tumors (CMTs) remains reliant on surgical resection and chemotherapy. However, these strategies are often limited by high recurrence…

Date: 2025-10-09

Production of functional CD19 CAR T cells under hypoxic manufacturing conditions

Abstract: Chronic lymphocytic leukemia (CLL) has proven difficult to treat with chimeric antigen receptor (CAR) T cell therapy. CLL cells can negatively alter T cell fitness and…

Date: 2025-10-08

The mediating role of social media disorder in the relationship between social media use and self-harm behavior in Indonesian adolescents

Abstract: Social media use in adolescence has been at an all-time high, along with the constant increase of self-harm behavior. Existing research on the relationship between…

Date: 2025-10-08