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Coordinated kinetics of humoral, T-cell, and cytokine responses to SARS-COV-2 in West African healthcare workers: a multicenter longitudinal study in university hospitals of Abidjan, Côte d’Ivoire

Abstract: Healthcare workers in resource-limited settings are frequently exposed to SARS-CoV-2, often with incomplete vaccine coverage. Yet, their adaptive immune responses remain…

Date: 2025-11-21

Suppression of NK cell-mediated immunosurveillance by IL-35 drives tumor progression in EGFR-mutant non-small cell lung cancer

Abstract: Interleukin-35 (IL-35) is an added member of the IL-12 heterodimeric cytokine family, composed of two subunits: EBI3 and P35 subunits, implicated in tumor immune…

Date: 2025-11-20

Integration of intratumoral/peritumoral radiomics and deep learning for predicting overall survival in non-small cell lung cancer patients: a multicenter study

Abstract: Prognostic assessment of non-small cell lung cancer (NSCLC) relies on TNM staging, yet tumor heterogeneity limits its accuracy. This study aimed to develop a model for…

Date: 2025-11-20

The crossroads of inflammation and nutrition: predicting neoadjuvant immunochemotherapy efficacy in esophageal squamous cell carcinoma patients

Abstract: Neoadjuvant immunochemotherapy (nICT) improves outcomes in esophageal squamous cell carcinoma (ESCC); however, patient response heterogeneity limits its clinical…

Date: 2025-11-20

Evaluation of AI-enhanced tele-ECG response time and diagnosis in acute chest pain patients

Abstract: The impact of artificial intelligence in improving Tele-ECG response times and diagnostic accuracy among emergency patients experiencing acute chest pain remains…

Date: 2025-11-20

Associations between gut microbiota and immune status in untreated B-cell lymphoma patients

Abstract: Emerging evidence links gut microbiota to tumorigenesis via immune modulation, though subtype-specific microbial signatures in B-cell lymphomas remain unclear. This…

Date: 2025-11-20

Identification and validation of mitochondrial and programmed cell death-related prognostic markers in pediatric acute myeloid leukemia

Abstract: Pediatric acute myeloid leukemia (AML) is characterized by poor prognosis and low survival rates following recurrence. While mitochondria and programmed cell death (PCD)…

Date: 2025-11-20

Association of thyroid hormone sensitivity indicators with visceral fat area in euthyroid overweight/obese type 2 diabetes patients: sex differences

Abstract: Thyroid hormone (TH) sensitivity plays a key role in glucose and lipid metabolism. However, its relationship with visceral fat distribution in euthyroid overweight/obese…

Date: 2025-11-20

Plasma oxytocin and leptin in relation to disordered eating: evidence from non-linear modeling across metabolic obesity phenotypes

Abstract: Obesity is heterogeneous across metabolic and behavioral dimensions. Oxytocin, a hypothalamic neuropeptide, and leptin, an adiposity signal, have been implicated in…

Date: 2025-11-20

The effect of broccoli stem extract cream ( Brassica oleracea L.) on macular scars post-acne

Abstract: Post-acne macular scars often cause skin discoloration, affecting appearance and self-confidence. To address this issue, various topical therapies have been developed.…

Date: 2025-11-20