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The ENTER study (E-DetectioN Tool for Emerging Mental DisoRders): general population recruitment and data integrity in online screening for psychosis risk

Abstract: Effective detection of young people at clinical high-risk for psychosis (CHR-P) is one of the rate-limiting steps in improving outcomes through preventive treatment.…

Date: 2025-11-18

Deep learning-assisted widefield endothelial imaging in Descemet membrane endothelial keratoplasty

Abstract: Significant endothelial cell density (ECD) losses in Descemet membrane endothelial keratoplasty (DMEK) can precipitate graft failure. Currently, clinical practice only…

Date: 2025-11-18

Mendelian randomization integrated with multi-omics analysis identifies TNIK as a key gene in gut microbiota-induced IBD development

Abstract: Dysbiosis of the gut microbiota (GM) has been linked to inflammatory bowel disease (IBD), yet its associated molecular mechanisms remain poorly defined. Identifying…

Date: 2025-11-18

Association between preoperative platelet count and transjugular intrahepatic portosystemic shunt procedure-related hemorrhage in cirrhotic patients: a retrospective study

Abstract: Transjugular intrahepatic portosystemic shunt (TIPS) is a high-bleeding-risk vascular intervention. The association between TIPS-related hemorrhage and preprocedural…

Date: 2025-11-18

Multiple mediators of anxiety and depression between living space and cognitive function among elderly patients with ischemic stroke

Abstract: To explore the relationship between living space, cognitive function, anxiety, and depression in ischemic stroke patients, specifically examining the mediating roles of…

Date: 2025-11-18

Influencing factors of emotional well-being in Chinese patients with gastroenteric tumours: the role of mindfulness practice, social support and patient-centred communication

Abstract: This study aimed to explore the factors influencing the emotional well-being of patients with gastroenteric tumours and to examine the mediating roles of beliefs about…

Date: 2025-11-17

Exploring motivations and barriers in prostate cancer screening: lessons from a volunteer-based MRI screening study

Abstract: Prostate cancer remains a significant public health challenge, an early detection with prostate-specific antigen (PSA) testing and biparametric MRI (bpMRI) can improve…

Date: 2025-11-17

Real-world data analysis of adjuvant capecitabine for triple-negative breast cancer after neoadjuvant chemotherapy

Abstract: Evaluate real-world outcomes in three cohorts of patients with early-stage triple-negative breast cancer (TNBC) treated with neoadjuvant chemotherapy (NAC): (1) patients…

Date: 2025-11-17

Impact of clinical and dosimetric factors on severe oral mucositis in head and neck cancer: insights from a phase II clinical trial

Abstract: Oral mucositis (OM) is the most common acute treatment-limiting adverse effect in patients with head and neck cancer (HNC), particularly following concomitant…

Date: 2025-11-17

Oxaliplatin versus irinotecan as first-line therapy in metastatic colorectal cancer with prior adjuvant treatment: a retrospective study on efficacy, sequential therapy, and the impact of thrombocytopenia

Abstract: The comparative efficacy of oxaliplatin versus irinotecan as first-line therapy in mCRC patients with prior adjuvant treatment remains unclear. To compare the efficacy…

Date: 2025-11-17