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First-line immune checkpoint inhibitors combined with chemotherapy in advanced large-cell neuroendocrine carcinoma of the lung: a real-world retrospective study

Abstract: Large-cell neuroendocrine carcinoma of the lung (LCNEC) shares clinicopathological features with both small cell lung cancer (SCLC) and non-small cell lung cancer…

Date: 2025-11-18

Prediction model and significance of myocardial injury induced by fluorouracil combined with platinum-based chemotherapy in advanced gastric cancer based on baseline data and inflammation-nutrition-atherosclerosis factors

Abstract: To develop and evaluate a predictive model for myocardial injury in patients with advanced gastric cancer treated with fluorouracil plus platinum-based chemotherapy,…

Date: 2025-11-18

How to predict progression-free survival in patients with grade 2 IDH-mutated diffuse gliomas after surgery: a long-term follow-up analysis

Abstract: Available prognostic scores for adult-type diffuse glioma with isocitrate dehydrogenase (IDH) mutant were validated before the evaluation of biomolecular features. The…

Date: 2025-11-18

Allogeneic hematopoietic stem cell transplantation for mixed-phenotype acute leukemia: a single-center study

Abstract: Mixed-phenotype acute leukemia (MPAL) is a rare subtype of acute leukemia with unfavorable outcome. There is no established optimal therapy regime. We conducted a…

Date: 2025-11-18

Global burden of anemia attributed to chronic kidney disease: prevalence, years lived with disability, and predictions to 2035 (Global burden of disease 2021)

Abstract: As a common complication of chronic kidney disease (CKD), anemia is associated with increased mortality and reduced quality of life. Despite its severe impact, there is…

Date: 2025-11-18

Analysis of ultrasound parameters influencing endometrial receptivity and a pregnancy outcomes predictive model for patients undergoing in vitro fertilization and embryo transfer: a prospective study

Abstract: This study aims to assess the impact of ultrasound parameters on endometrial receptivity in patients undergoing IVF-ET and to establish a predictive model for ongoing…

Date: 2025-11-18

An explainable machine learning model for predicting preterm birth in pregnant women with gestational diabetes mellitus and hypertensive disorders of pregnancy: development and external validation

Abstract: Gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) often coexist and share pathophysiological features such as insulin resistance and…

Date: 2025-11-18

Development of a risk prediction model for acute kidney injury in liver transplant recipients

Abstract: To develop and internally validate a nomogram for early postoperative prediction of acute kidney injury (AKI) within 7 days after orthotopic liver transplantation (LT).…

Date: 2025-11-18

The Family Stress Model in families of children with rare diseases: a cross-sectional multilevel path analysis for understanding family dynamics

Abstract: Theoretical frameworks, such as the Family Stress Model, have been evaluated in various contexts; however, there is a lack of large-scale studies specifically focusing…

Date: 2025-11-18

Improving adolescents’ knowledge about mental health and depression: a randomized experimental study of web-based information

Abstract: Adolescents often lack adequate knowledge about mental health and available professional support, which hinders timely help-seeking. As many adolescents seek information…

Date: 2025-11-18