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Perforator mapping for head and neck reconstructive surgery: a novel personalized approach using magnetic resonance angiography based 3D models and 3D-printing

Abstract: Reconstruction of large head and neck defects in oncologic patients often requires free vascularized tissue flaps. Successful flap design and elevation depend on…

Date: 2025-09-30

Immunotherapy combined with definitive chemoradiotherapy for locally advanced unresectable esophageal squamous cell carcinoma

Abstract: The clinical value of immune checkpoint inhibitors (ICIs) in the treatment of unresectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) remains under…

Date: 2025-09-30

Spectrum of care approach to animal shelter management of feline infectious peritonitis complicated by feline leukemia virus

Abstract: Feline infectious peritonitis (FIP) occurs most commonly in multi-cat environments such as animal shelters. FIP is often suspected based on compatible history,…

Date: 2025-09-29

Lithospermum erythrorhizon extract alleviates immunosuppression via MAPK signaling pathway

Abstract: Lithospermum erythrorhizon extract (LEE), rich in shikonin and its derivatives, has been traditionally valued for anti-inflammatory and wound-healing properties. This…

Date: 2025-09-29

Environmental noise and self-rated health in older surgical patients undergoing general anesthesia: a cross-sectional study of anxiety as a behavioral pathway for healthy aging

Abstract: Promoting healthy aging—a core public-health objective—demands hospital environments that support functional recovery and well-being. Excessive ward noise, however, is a…

Date: 2025-09-29

Electroencephalogram prediction of propofol effects on neuromodulation in disorders of consciousness

Abstract: This study aimed to characterize electroencephalogram (EEG) responses to low-dose propofol anesthesia in patients with disorders of consciousness (DoC) of distinct…

Date: 2025-09-29

Prevalence and associated factors of mental distress among private college nursing students in Gondar town, Northwest Ethiopia, 2023

Abstract: Mental distress (MD) refers to a range of troubling, confusing, or unusual internal experiences and symptoms that affect more than 25% of people during their lives.…

Date: 2025-09-29

Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma

Abstract: Lung adenocarcinoma is the most prevalent lung cancer type, with a 5-year survival rate for advanced patients below 20%. This study aims to develop a risk model to guide…

Date: 2025-09-29

Comparison of efficacy and side effects between short-course radiotherapy and chemotherapy with or without immunotherapy in the neoadjuvant treatment for patients with locally advanced rectal cancer

Abstract: To evaluate the efficacy and safety of short-course radiotherapy (SCRT) combined with chemotherapy (ChT) with or without immunotherapy (IT) in the neoadjuvant treatment…

Date: 2025-09-29

Strategy to select nasopharyngeal cancer patients for adaptive radiotherapy

Abstract: Nasopharyngeal cancer (NPC) patients experience significant anatomical changes during radiation treatment (RT). Adaptive radiotherapy (ART) can be initiated in response…

Date: 2025-09-29