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Association between ambient air pollution and outpatient visits for primary acquired lacrimal duct obstruction in Hangzhou, China

Abstract: Primary acquired lacrimal duct obstruction (PALDO) is the most common lacrimal drainage disease in clinics, which can be caused by multiple factors. However, few studies…

Date: 2025-09-29

PD-L1 expression in cerebrospinal fluid for leptomeningeal metastasis from solid tumors: preliminary assessment of clinical implications

Abstract: Intrathecal immune checkpoint inhibitors have shown promise for leptomeningeal metastasis (LM). Programmed cell death ligand 1 (PD-L1) is currently the primary…

Date: 2025-09-29

Real-world disproportionality analysis of cardiac failure associated with novel antineoplastic agents in breast cancer: a pharmacovigilance study

Abstract: Some antineoplastic agents have been implicated in cardiac failure (CF), but large-scale real-world data remain limited. This study aimed to assess disproportional…

Date: 2025-09-29

Dosimetric evaluations using cycle-consistent generative adversarial network synthetic CT for MR-guided adaptive radiation therapy

Abstract: Magnetic resonance (MR) guided radiation therapy combines high-resolution image capabilities of MRI with the precise targeting of radiation therapy. However, MRI does…

Date: 2025-09-29

Herring oil rich in long-chain monounsaturated fatty acid (C22: 1n-11) lowers plasma lipids and modulates fatty acid composition, oxidation, and inflammation in rats

Abstract: Marine oils and fatty fish rich in long-chain n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (C20:5n-3, EPA) and docosahexaenoic acid (C22:6n-3,…

Date: 2025-09-26

A real-world data study of the effect of co-solvent differences on the clinical safety of melphalan for injection

Abstract: This study aimed to compare the efficacy and safety of myeloablative conditioning with high-dose propylene glycol-free melphalan (PGF-Mel, EVOMELA ® ) versus propylene…

Date: 2025-09-26

Next-generation sequencing reveals clinical features and prognosis of gene mutations in Chinese children with T-cell acute lymphoblastic leukaemia

Abstract: The 5-year overall survival (OS) for paediatric T-cell acute lymphoblastic leukaemia (T-ALL) exceeds 80% under the current treatment strategies; however, some patients…

Date: 2025-09-26

Morphofunctional parameters as predictors of autologous hematopoietic stem cell transplantation outcomes

Abstract: There is a lack of predictive factors for specific complications in patients who undergo autologous hematopoietic stem cell transplantation. A complete morphofunctional…

Date: 2025-09-26

The impact of short-term comprehensive treatment on cardiovascular-kidney-metabolic syndrome and its components in patients with type 2 diabetes

Abstract: The purpose of this study was to evaluate the interaction of risk factors and effects of short-term comprehensive treatment on the staging and components of…

Date: 2025-09-26

Association between life’s crucial 9 and sarcopenia: estimated glucose disposal rate as a key mediator

Abstract: Studies indicate an association between cardiovascular health and sarcopenia (SP). Insulin resistance is significantly linked to both cardiovascular disease and…

Date: 2025-09-26