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Higher aged neutrophils and differential inflammatory profiles in sickle cell disease patients on chronic transfusion therapy versus those on hydroxyurea

Abstract: Sickle cell disease (SCD) is characterized by a point mutation in the ? globin molecule, causing the sickling of red blood cells, and leading to hemolytic anemia, pain,…

Date: 2025-09-26

Benefits of multi-micronutrient nutritional formula combined with aerobic exercise on children with attention deficit hyperactivity disorder: improvements in symptoms, cognition, executive function, and sleep

Abstract: Attention-Deficit/Hyperactivity Disorder (ADHD) affects approximately 5% of children globally and is characterized by symptoms of inattention, hyperactivity, and…

Date: 2025-09-26

Plasma amino acid profiles in pediatric obesity: potential biomarkers for the early assessment of metabolic risk

Abstract: Childhood obesity is among the most serious and rapidly growing public health issues globally. Although body mass index (BMI) is commonly used to evaluate obesity, it…

Date: 2025-09-26

Application of algorithms based on improved YOLO in MRI image detection of brain tumors

Abstract: Brain tumors, characterized by irregular cell growth in the brain or surrounding tissues, encompass aggressive types like glioblastoma and more indolent forms such as…

Date: 2025-09-26

Recreational MDMA use in Norway: results from an internet convenience sample

Abstract: In recent years, a renewed interest has emerged in investigating the use of MDMA in the treatment of mental disorders. However, knowledge about the characteristics of…

Date: 2025-09-26

Right atrial and right ventricular strain in patients with acute decompensated heart failure: a pilot study

Abstract: The aim of this study was to compare the right atrial (RAS: reservoir-R, conduit-CD, contraction-CT) and right ventricular strain (global longitudinal-RV-GS, free wall…

Date: 2025-09-26

Predictive models for non-response to conventional treatment in polymyositis and dermatomyositis

Abstract: Polymyositis (PM) and dermatomyositis (DM) are the major subtypes of idiopathic inflammatory myopathies with heterogeneous treatment responses. This study aimed to…

Date: 2025-09-26

HuR ablation destabilizes Foxp3 mRNA and impairs regulatory T cell function, contributing to an autoimmune phenotype

Abstract: The RNA-binding protein HuR (Elavl1), a key post-transcriptional regulator, plays a critical role in T cell activation and function by stabilizing target mRNAs. To…

Date: 2025-09-26

Scientific and regulatory progress in advancing paediatric oncology drug development in the EU and in the US

Abstract: This study provides an updated overview of progress in paediatric oncology, following legislative and regulatory initiatives in the European Union (EU) and in the United…

Date: 2025-09-26

Dendrobium huoshanense C. Z. Tang & S. J. Cheng alleviates atherosclerosis by reducing lipid and improving vascular endothelial dysfunction

Abstract: Dendrobium huoshanense C. Z. Tang & S. J. Cheng (DH) water extract has previously been found to have therapeutic effects on atherosclerosis (AS), but the active…

Date: 2025-09-26