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Wavering between life and death: a qualitative study into the perceived causes and needs of persons with persistent suicidality

Abstract: One of the key issues in the current knowledge base on persistent or chronic suicidality is the discrepancy between the extensive experiential knowledge embedded in…

Date: 2025-10-24

Changes in human tear metabolome following topical 0.05% cyclosporine A on primary Sjögren’s syndrome

Abstract: This study aimed to investigate changes in the tear metabolome and the therapeutic impact of 0.05% cyclosporine A (CsA) eye drops in patients with dry eye disease (DED)…

Date: 2025-10-24

NF-?B/IL-6 axis drives impaired corneal wound healing in aqueous-deficient dry eye

Abstract: Dry eye disease (DED) commonly leads to compromised corneal epithelial integrity and chronic ocular surface inflammation; however, the precise molecular mechanisms…

Date: 2025-10-24

Exploring the S-shaped relationship between triglyceride-glucose index and serum uric acid levels in individuals with osteoporotic fracture

Abstract: The triglyceride-glucose index (TyG) has been linked to metabolic disorders, yet its association with serum uric acid (SUA) in elderly osteoporosis patients remains…

Date: 2025-10-24

Comprehensive genetic screening of 70 severe adolescent idiopathic scoliosis probands reveals novel pathogenic variants and syndromic associations

Abstract: Idiopathic scoliosis (IS) is a complex spinal deformity affecting ~3% of the population, with a multifactorial and genetically heterogeneous origin. This study aimed to…

Date: 2025-10-24

Long-term survival outcomes of Wagner™ conical stems in crowe non-IV hip dysplasia: a retrospective analysis

Abstract: Total hip arthroplasty (THA) is one of the most frequently performed orthopedic procedures. Developmental dysplasia of the hip (DDH) presents specific anatomical…

Date: 2025-10-24

Disseminated Kaposi sarcoma patients exhibit an expanded population of CD8+CD57+ T cells and an immunosenescence profile

Abstract: Kaposi’s sarcoma herpesvirus (KSHV) remains the most common opportunistic malignancy that contributes to morbidity and mortality among persons living with HIV (PLWH)…

Date: 2025-10-24

Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages

Abstract: NLRP3 (NLR family pyrin domain-containing 3) inflammasome is a first line of defense of innate immunity, mediating caspase-1-dependent pyroptosis and cytokine release…

Date: 2025-10-24

The global burden of hypertension and its epidemiological impacts on adolescents and young adults: projections to 2050

Abstract: To deeply analyze the epidemiological characteristics of the disease burden of hypertension and its related damages among adolescents and young adults aged 15–39…

Date: 2025-10-24

Association of social determinants of health and their cumulative inequities with risk of hypertension: a population-based study

Abstract: Hypertension remains a global public health challenge with significant socioeconomic disparities. While traditional risk factors are well-documented, the cumulative…

Date: 2025-10-24