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The global epidemiology of gastrointestinal cancer burden attributable to dietary risks: a systematic analysis of the Global Burden of Disease Study 2021

Abstract: Gastrointestinal (GI) cancers collectively account for over 30% of global cancer-related mortality, with diet and nutrition playing crucial roles in their development.…

Date: 2025-10-23

Preserved ictal responsiveness in right mesial temporal lobe epilepsy: metabolic correlates in posterior temporal networks with FDG-PET

Abstract: Automatisms with preserved responsiveness (APR) represent a distinctive clinical feature in right mesial temporal lobe epilepsy (MTLE). This study aimed to investigate…

Date: 2025-10-23

Myelin oligodendrocyte glycoprotein antibody-associated isolated aseptic meningitis: a single?center pediatric case series

Abstract: Aseptic meningitis represents a rare and underrecognized phenotype of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD). Despite sporadic…

Date: 2025-10-23

The neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with neuromyelitis optica spectrum disorders and multiple sclerosis

Abstract: This study aimed to investigate the differences in neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) between patients with neuromyelitis optica…

Date: 2025-10-23

Monocyte-driven IFN and TNF programs orchestrate inflammatory networks in antisynthetase syndrome-associated interstitial lung disease

Abstract: Antisynthetase syndrome-associated interstitial lung disease (ASS-ILD) exhibits clinical heterogeneity and progression, with unclear immunopathogenic mechanisms. This…

Date: 2025-10-23

Anti-ALDOA antibody: a novel diagnostic-associated autoantibody in myasthenia gravis

Abstract: This study identified novel autoantibodies in patients with seronegative myasthenia gravis (SNMG).Autoantibodies in SNMG sera were screened using a targeted binding…

Date: 2025-10-23

HOXA5-mediated spatial remodeling of tumor-immune interfaces across cancers promotes AML pathogenesis

Abstract: HOXA5 (homeobox A5) exhibits context-dependent roles in cancer, but its pan-cancer spatial immune regulatory functions and therapeutic potential remain poorly…

Date: 2025-10-23

Benralizumab for adults with rare and off-label eosinophilic disorders: a 52-week prospective, single-center study

Abstract: Rare eosinophilic disorders are challenging to manage due to their heterogeneity and lack of targeted therapies. Benralizumab, an anti-IL-5 receptor monoclonal antibody…

Date: 2025-10-23

Exploratory investigation of dose calculation and tumor-feeding artery identification using dual CBCT in selective internal radiation therapy with Yttrium-90 microspheres

Abstract: To explore the preliminary application of dual cone-beam CT (CBCT) for dose calculation and tumor-feeding arteries identification in 90 Y-SIRT planning. A retrospective…

Date: 2025-10-23

Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma

Abstract: We have previously shown inhaled IL-15 is associated with anti-tumor responses in dogs with metastatic osteosarcoma (OSA) and melanoma. We evaluated inhaled IL-15…

Date: 2025-10-23