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Dynamic performance and scenario-based screening strategy of six COPD questionnaires: a cross-sectional study with prevalence-driven robustness validation

Abstract: Chronic Obstructive Pulmonary Disease (COPD) imposes a high global burden. Spirometry is the diagnostic gold standard but has accessibility barriers. Screening…

Date: 2025-09-24

Global burden of childhood Burkitt lymphoma (1990–2021): epidemiological trends, regional disparities, and projections for 2035 from the Global Burden of Disease Study

Abstract: Burkitt lymphoma (BL) is a highly aggressive pediatric B-cell lymphoma with marked geographic heterogeneity. Up-to-date global estimates are needed to inform prevention…

Date: 2025-09-24

Variants of unknown significance in fetal heart malformations: distribution and impact on prenatal decision-making

Abstract: To investigate the distribution patterns of variants of unknown significance (VUS) in fetuses with heart malformations (CHD) combined with extracardiac abnormalities and…

Date: 2025-09-24

The use of thyroid hormones in the treatment of euthyroid patients with treatment-resistant depression. Data from a survey of 5695 European national endocrine professional organization members

Abstract: Treatment-resistant depression (TRD) is most commonly defined as depression that has not responded to two different pharmacological agents used for an adequate period of…

Date: 2025-09-23

Drug-induced Sweet’s syndrome: pharmacovigilance insights from FAERS with a cross-database consistency assessment in VigiBase via LASSO and multivariable logistic regression

Abstract: Drug-induced Sweet’s syndrome (DISS), a rare but serious adverse drug reaction characterized by acute febrile neutrophilic dermatosis, remains difficult to identify due…

Date: 2025-09-23

Peripheral monocytes from Crohn’s disease patients retain functional responsiveness to GM-CSF during active disease

Abstract: Crohn’s disease (CD) is a relapsing inflammatory disease that is currently not curable. Despite the availability of anti-inflammatory treatments, 30–60% of patients…

Date: 2025-09-23

Comparison of the effectiveness of vitrectomy with silicone oil or perfluoropropane tamponade for myopic foveoschisis with foveal detachment

Abstract: Vitrectomy with silicone oil or perfluoropropane (C3F8) tamponade is a standard of treatment for myopic foveoschisis with foveal detachment (MFFD). In this study, we…

Date: 2025-09-23

Development and validation of a deep learning model using MR imaging for predicting brain metastases: an accuracy-focused study

Abstract: Brain metastases (BM), originating from extracranial malignancies, significantly threaten patient health. Accurate BM identification is crucial but labor-intensive…

Date: 2025-09-23

Fungal communities in Florida salt marsh mosquito midguts vary between species and over time but have low structure

Abstract: Microorganisms are intrinsically tied to the developmental and reproductive success of mosquitoes, can influence their ability to resist insecticides, and can strongly…

Date: 2025-09-23

Development of a nomogram model for predicting coronary heart disease in patients with metabolic-associated fatty liver disease

Abstract: To investigate the risk factors associated with coronary heart disease (CHD) in patients with metabolic-associated fatty liver disease (MAFLD) and develop a nomogram…

Date: 2025-09-23