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What do older people who have attempted suicide experience? Study protocol for a qualitative meta-synthesis among older adults, family caregivers and healthcare professionals

Abstract: Introduction Attempted suicide among older adults represents a significant mental health concern that has witnessed a rising incidence within this demographic in recent…

Date: 2023-12-09

ProFertil study protocol for the investigation of gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy aiming at fertility protection of young women and teenagers with cancer in Sweden—a phase III randomised double-blinded placebo-controlled study

Abstract: Background Gonadotropin-releasing hormone agonists (GnRHa) cotreatment used to transiently suppress ovarian function during chemotherapy to prevent ovarian damage and…

Date: 2023-12-09

Key performance indicators in extracorporeal membrane oxygenation (ECMO): protocol for a systematic review

Abstract: Introduction Extracorporeal membrane oxygenation (ECMO) is an intervention used in critically ill patients with severe cardiopulmonary failure that is expensive and…

Date: 2023-12-09

Large language model-based information extraction from free-text radiology reports: a scoping review protocol

Abstract: Introduction Radiological imaging is one of the most frequently performed diagnostic tests worldwide. The free-text contained in radiology reports is currently only…

Date: 2023-12-09

Effects of repetitive transcranial magnetic stimulation over the contralesional dorsal premotor cortex on upper limb function in severe ischaemic stroke: study protocol for a randomised controlled trial

Abstract: Introduction Repetitive transcranial magnetic stimulation (rTMS) is an evidence-based treatment widely recommended to promote hand motor recovery after ischaemic stroke.…

Date: 2023-12-09

Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration

Abstract: Introduction Alzheimer’s disease and other dementias affect >50?million individuals globally and are characterised by broad clinical and biological heterogeneity. Cohort…

Date: 2023-12-09

Methodology and application of three-dimensional technology for brace design and production for treatment in patients with adolescent idiopathic scoliosis: a scoping review protocol

Abstract: Introduction Conservative treatment for adolescent idiopathic scoliosis (AIS) using bracing has proven to be effective at reducing curve progression. However, variation…

Date: 2023-12-09

Effects of the different intensities of task-oriented training on the upper extremity motor function and self-care ability of stroke survivors: study protocol for a multiarm parallel-group randomised controlled trial in a tertiary hospital in China

Abstract: Introduction Although task-oriented training (TOT) may provide added therapeutic value to stroke survivors, current TOT guidance offers insufficient advice on…

Date: 2023-12-09

Differentiating Alzheimer’s disease from mild cognitive impairment: a quick screening tool based on machine learning

Abstract: Background Alzheimer’s disease (AD) is a neurodegenerative disorder characterised by cognitive decline, behavioural and psychological symptoms of dementia (BPSD) and…

Date: 2023-12-09

Investigating trial design variability in trials of disease-modifying therapies in Parkinson’s disease: a scoping review protocol

Abstract: Introduction Parkinson’s disease (PD) is a debilitating neurological disorder for which the identification of disease-modifying interventions represents a major unmet…

Date: 2023-12-09