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Corticosteroids in sepsis and community-acquired pneumonia

Abstract: Sepsis and septic shock, which are often caused by pneumonia, impact millions of people every year. Despite adequate antibiotic therapy, mortality remains high, up to…

Date: 2023-12-05

Competing treatments for migraine: a headache for decision-makers

Abstract: Migraine is the world’s second most common disabling disorder, affecting 15% of UK adults and costing the UK over £1.5 billion per year. Several costly new drugs have…

Date: 2023-12-05

Pathogenic monoallelic variants in GLIS3 increase type 2 diabetes risk and identify a subgroup of patients sensitive to sulfonylureas

Abstract: GLIS3 encodes a transcription factor involved in pancreatic beta cell development and function. Rare pathogenic, bi-allelic mutations in GLIS3 cause syndromic neonatal…

Date: 2023-12-05

Giant non-parasitic splenic cyst: a case report

Abstract: Splenic cysts are quite rare and asymptomatic. They may result from infection by a parasite, especially Echinococcus granulosus (hydatid cyst), or from non-parasitic…

Date: 2023-12-05

Association between body mass index and myopia in the United States population in the National Health and Nutrition Examination Surveys 1999 to 2008: a cross-sectional study

Abstract: This study investigated the association between body mass index (BMI) and myopia in the United States.

Date: 2023-12-05

E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the ?-catenin/HIF-1? positive feedback loop in chronic rhinosinusitis with nasal polyps

Abstract: Chronic rhinosinusitis with nasal polyp (CRSwNP) is a refractory inflammatory disease with epithelial-mesenchymal transition (EMT) as one of the key features. Since…

Date: 2023-12-05

An integrative evaluation of circadian gene TIMELESS as a pan-cancer immunological and predictive biomarker

Abstract: The gene TIMELESS, which is involved in the circadian clock and the cell cycle, has recently been linked to various human cancers. Nevertheless, the association between…

Date: 2023-12-05

Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors

Abstract: As the incidence of neuroendocrine tumors has been rising, gender differences in epidemiology and clinical behavior have emerged, and interest into a gender-driven…

Date: 2023-12-05

What to do with non-responders to CGRP(r) monoclonal antibodies: switch to another or move to gepants?

Abstract: In this editorial we aim to provide potential therapeutic options in patients who do not benefit from treatment with CGRP(r) monoclonal antibodies. Based on current…

Date: 2023-12-05

Associations of medicine use and ejection fraction with the coexistence of frailty and sarcopenia in a sample of heart failure outpatients: a cross-sectional study

Abstract: Frailty and sarcopenia have been extensively studied in heart failure (HF) patients, but their coexistence is unknown. The aim of this work is to describe the…

Date: 2023-12-05