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Marked under-diagnosis of Lambert-Eaton myasthenic syndrome in small cell lung cancer: an analysis of real-world claims data

Abstract: Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune neurologic condition causing progressive muscle weakness that can occur as a paraneoplastic disorder, most…

Date: 2025-10-17

Co-occurrence patterns of esophageal and stomach cancer across 204 countries and territories: a spatial correspondence and systematic analysis

Abstract: Esophageal and gastric cancers are common malignant tumors of the digestive tract worldwide, characterized by a substantial disease burden and significant regional…

Date: 2025-10-17

Development and validation of an interpretable machine learning model for acute radiation dermatitis in breast cancer

Abstract: Radiation dermatitis (RD), a common adverse reaction in breast cancer radiotherapy, impairs quality of life and increases healthcare burdens. Developing an effective…

Date: 2025-10-17

Correlation of immune cell subsets in the tumor microenvironment and peripheral blood with immunotherapy response in esophageal squamous cell carcinoma

Abstract: Esophageal squamous cell carcinoma (ESCC) is commonly diagnosed at an advanced stage, where conventional chemoradiotherapy offers only limited clinical benefit. Immune…

Date: 2025-10-17

Machine learning model for predicting epidermal growth factor receptor expression status in breast cancer using ultrasound radiomics

Abstract: The epidermal growth factor receptor (EGFR) is a clinically important target, as its expression in patients with breast cancer influences both overall and disease-free…

Date: 2025-10-17

Modest radiation dose escalation for early-stage anal cancer: cancer control and toxicity outcomes

Abstract: The optimal dose for patients with early-stage squamous cell carcinoma of the anus (SCCA) is unknown. We aimed to evaluate the impact of modest dose escalation (54 Gray…

Date: 2025-10-17

Machine learning-based predictive model for immune checkpoint inhibitors response in gastrointestinal cancers

Abstract: Gastrointestinal (GI) cancers present significant clinical challenges characterized by dismal survival outcomes and suboptimal prognoses. Currently, only partial…

Date: 2025-10-17

A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry

Abstract: Antiphospholipid syndrome (APS) is an autoimmune disease with thromboembolic and obstetric morbidity arising via a model of immunothrombosis. Individuals with APS may…

Date: 2025-10-16

B7-H7 knockdown suppresses the proliferation, metastasis, and drug resistance of B-cell non-Hodgkin lymphoma cells by inhibiting the PI3K/Akt pathway

Abstract: The activation of key immune regulatory factors is an important driving factor in the progression of therapeutic resistance in patients with B-NHL. As a novel immune…

Date: 2025-10-16

Systemic immune inflammation index guides machine learning for rapid TTP diagnosis: a retrospective cohort study

Abstract: Thrombotic thrombocytopenic purpura (TTP) is a rare, life threatening thrombotic microangiopathy that requires prompt diagnosis to reduce mortality. However, its early…

Date: 2025-10-16