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MHC class II presentation of FVIII-AnnexinA5 fusion proteins internalized by antigen presenting cells

Abstract: The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) remains the most serious complication in the treatment of hemophilia A.…

Date: 2025-09-25

SLC43A2-mediated immune cell infiltration: a potential therapeutic target in acute myeloid leukemia

Abstract: Tumor cells compete with T cells for methionine by overexpressing SLC43A2 (solute carrier family 43 member 2), leading to T cell exhaustion. However, the correlation…

Date: 2025-09-25

Incidence trends and survival analysis of enteropathy-associated T-cell lymphoma

Abstract: Enteropathy-associated T-cell lymphoma (EATL) is a rare, aggressive form of T-cell non-Hodgkin lymphoma, primarily affecting the small intestine. Due to its extremely…

Date: 2025-09-25

Obesity-related knowledge, attitude, and practices among primary care physicians in China: a cross-sectional study

Abstract: Obesity is a major global public health crisis but remains inadequately addressed during clinical encounters. In China, the primary healthcare system plays a vital role…

Date: 2025-09-25

Association of acyl-CoA oxidase-like gene polymorphisms with risk, onset age, and beta-cell function of type 1 diabetes in Chinese

Abstract: Genome-wide association studies in Caucasians suggested an association between the acyl-CoA oxidase-like ( ACOXL ) gene and type 1 diabetes (T1D). We investigated if…

Date: 2025-09-25

Contrasting associations of body mass index and waist circumference with cancer incidence in the elderly: a nationwide population-based study

Abstract: Obesity has been reported to be associated with increased cancer risk. Body mass index (BMI) and waist circumference (WC) are representative measures of adiposity, but…

Date: 2025-09-25

Human milk-derived 5?-UMP promotes thermogenesis and mitochondrial biogenesis to ameliorate obesity

Abstract: Traditional obesity interventions are often unsuitable for children. Breastfeeding has been shown to reduce obesity risk, potentially through bioactive metabolites in…

Date: 2025-09-25

Diagnostic and therapeutic pitfalls in the management of pediatric patients with 3?-hydroxysteroid dehydrogenase type 2 (3?-HSD2) deficiency - a single center experience

Abstract: Congenital adrenal hyperplasia (CAH) due to 3?-hydroxysteroid dehydrogenase type 2 deficiency (3?-HSD2D) is an exceptionally rare disorder affecting adrenal…

Date: 2025-09-25

Unveiling new insights: a comprehensive questionnaire-based single-center study of sebaceous nevus

Abstract: Sebaceous nevus (SN) is a rare, benign, congenital tumor. There is limited information on its clinical features, familial influences, quality of life (QoL) impact, and…

Date: 2025-09-25

Leveraging anatomy to improve safety and efficacy in temple augmentations—a case series of 20 patients

Abstract: Temple augmentation has become a cornerstone in full-face aesthetic rejuvenation, yet traditional techniques often face limitations, including aesthetic limitations and…

Date: 2025-09-25