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The exploration of using plasma biomarkers of p-tau217 and p-tau181 for screening Alzheimer’s disease in very elderly people

Abstract: Blood-based biomarkers for Alzheimer’s disease (AD), such as phosphorylated tau (p-tau181, p-tau217) and amyloid beta (A?), have the potential to serve as screening…

Date: 2025-10-16

Toward precision psychiatry: theoretical implications of bimodal response patterns to vasopressin V1b receptor inhibition in depression

Abstract: Despite extensive research and numerous available treatments, major depressive disorder (MDD) remains a significant global health issue with limited efficacy from…

Date: 2025-10-16

ATF3 prevents retinal ganglion cell apoptosis and mitigates microglia-mediated neuroinflammation in retinal ischemia–reperfusion injury

Abstract: Neuroinflammation is a key pathological response involved in secondary optic nerve injury following retinal ischemia–reperfusion injury. The expression of activating…

Date: 2025-10-16

Predictive value of hyperreflective foci for anti-VEGF therapeutic outcomes in different subtypes of diabetic macular edema: a retrospective analysis

Abstract: To analyze the correlation between optical coherence tomography (OCT) biomarkers and therapeutic outcomes in patients with different subtypes of diabetic macular edema…

Date: 2025-10-16

Clinical performance of the pseudo-non diffracting beam Toric EDOF intraocular lens: visual function, rotational stability, and quality of life

Abstract: To evaluate visual acuity, refractive outcomes, rotational stability, and patient-reported satisfaction 3?months after bilateral implantation of the Lucidis Toric…

Date: 2025-10-16

The association between peripheral blood inflammatory markers and anti-VEGF treatment response in patients with type 2 diabetic macular edema

Abstract: This study aimed to investigate the correlation between serum inflammatory markers of patients with diabetic macular edema (DME) and the efficacy of intravitreal…

Date: 2025-10-16

Night shift work increases the risk of developing irritable bowel syndrome: a prospective cohort study in the UK Biobank

Abstract: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with a substantial disease burden. Night shift work has become increasingly common…

Date: 2025-10-16

Association between serum albumin-to-globulin ratio and subtypes of cerebral atherosclerotic stenosis in acute ischemic stroke

Abstract: The albumin-to-globulin ratio (AGR) is a biomarker reflecting both nutritional status and inflammation, which has recently been implicated in the development of ischemic…

Date: 2025-10-16

Clinical features and prognosis of the adult patients positive for both N-methyl-d-aspartate receptor and myelin oligodendrocyte glycoprotein antibodies

Abstract: The coexistence of the MOG antibody (MOG-ab) and NMDAR antibody (NMDAR-ab), which is known as the MOG-ab and NMDAR-ab overlapping syndrome (MNOS), is the most common in…

Date: 2025-10-16

Cardiac abnormalities and repolarization variability in epilepsy: influence of antiseizure medications and treatment response

Abstract: This study aimed to investigate the effects of different antiseizure medications (ASMs) and clinical treatment response on interictal electrocardiographic (ECG)…

Date: 2025-10-16