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H3K27me3 and HOXA9 expression predict prognosis in pediatric acute myeloid leukemia: an epigenetic-transcriptional correlation study

Abstract: Epigenetic dysregulation plays a central role in pediatric acute myeloid leukemia (AML), yet its clinical relevance remains underexplored. This study primarily aimed to…

Date: 2025-09-25

Clinical, immunological, molecular characteristics and outcomes of stem cell transplantation in ZAP70 deficiency: a single-center experience

Abstract: Zeta-chain-associated protein kinase 70 ( ZAP70 ) deficiency is a rare autosomal recessive T + B + NK + combined immunodeficiency characterized by heterogeneous clinical…

Date: 2025-09-25

Application of drug-induced sleep endoscopy in infants with dynamic upper airway collapse

Abstract: The study aimed to evaluate the utility and safety of drug-induced sleep endoscopy (DISE) in infants with suspected dynamic upper airway collapse. Infants with suspected…

Date: 2025-09-25

Evaluating stress and it associated factors in mothers of preterm infants in NICU: a cross-sectional study

Abstract: Providing care of preterm infants in the NICU is a significant source of psychological and emotional stress for both infants and parents. The purpose of the study was to…

Date: 2025-09-25

Clinical and immunological characterization of a Netherton syndrome infant with a large SPINK gene cluster deletion and a c.1258A>G polymorphism in SPINK5

Abstract: Netherton syndrome (NS) is a rare autosomal recessive disorder caused by mutations in the SPINK5 gene, which encodes the serine protease inhibitor LEKTI. It is…

Date: 2025-09-25

TACI and BTK gene analysis in predominantly antibody deficiencies among the primary immunodeficiency disorder patients in Bangladesh

Abstract: Common variable immune deficiency disorder (CVID) and X-linked agammaglobulinemia (XLA) are the most prevalent predominantly antibody deficiencies (PADs). Analysis of…

Date: 2025-09-25

Can the triglyceride–glucose index identify prediabetes in children and adolescents with obesity? a cross-sectional study

Abstract: This study aims to evaluate the triglyceride–glucose (TyG) index as a biomarker for identifying prediabetes mellitus (PDM) in children and adolescents with obesity and…

Date: 2025-09-25

Spectral detector computed tomography imaging of histologically confirmed splenic pathologies in 30 canine patients: a comparison of virtual non-contrast images and true unenhanced images

Abstract: Spectral detector computed tomography (SDCT), a cutting-edge technique in veterinary medicine, offers various options for characterizing soft tissues. One such option is…

Date: 2025-09-25

Artificial neural network-augmented dosiomic integration for predicting distant recurrence in NSCLC patients treated with SBRT

Abstract: Stereotactic body radiotherapy (SBRT) is a standard curative treatment for inoperable early-stage non-small cell lung cancer (NSCLC) patients. However, the high rate of…

Date: 2025-09-25

Positive association between Cheyne-Stokes respiration events and diastolic dysfunction in pre-heart failure: a cross-sectional study with longitudinal implications

Abstract: Cheyne-Stokes respiration (CSR), a distinct type of sleep-related breathing disorder, is closely associated with heart failure (HF). In clinical practice, it has been…

Date: 2025-09-25