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Shared decision-making among older adults with multimorbidity in Kerala’s primary care: a qualitative study using the socio-ecological model

Abstract: Multimorbidity is an increasing public health challenge among older adults, particularly in Kerala, India. Shared decision-making (SDM) is central to person-centered…

Date: 2025-09-25

Establishment and validation of a prognostic model based on vasculogenic mimicry-related gene clustering in ovarian cancer

Abstract: As a critical prognostic factor in ovarian cancer which is the most lethal gynecologic malignancy, vasculogenic mimicry (VM) has not been systematically incorporated…

Date: 2025-09-25

Profiling of immune cell subsets and functional characteristics of cervical cancer based on single cell RNA sequencing

Abstract: A comprehensive characterization of immune cells within the tumor microenvironment (TME) of cervical squamous cell carcinoma (CSCC) is essential to advance understanding…

Date: 2025-09-25

Causal relationship between gut microbiota and diabetic neuropathy: a Mendelian randomization and 16S rRNA sequencing analysis

Abstract: Evidence suggests a link between gut microbiota and diabetes mellitus, yet the specific role in diabetic peripheral neuropathy (DPN) remains elusive. The study aims to…

Date: 2025-09-25

Zinc deficiency as a contributor to acute kidney injury in patients with chronic kidney disease: a propensity score–matched retrospective analysis

Abstract: Acute kidney injury (AKI) is a frequent and serious complication in patients with chronic kidney disease (CKD) that often leads to poor clinical outcomes. Despite the…

Date: 2025-09-25

Impact of hypercoagulable state on Crohn’s disease severity and progression: transcriptomic and single-cell analyses of the ileum

Abstract: The mechanisms linking hypercoagulability to disease severity in Crohn’s disease (CD) remain poorly understood. Through integrated transcriptomic and single-cell…

Date: 2025-09-25

Global, regional, and national burden of hyperglycemia-associated colorectal cancer, 1990-2021: a systemic analysis for the Global Burden of Disease study

Abstract: Colorectal cancer (CRC) is a leading gastrointestinal malignancy with rising incidence. Hyperglycemia emerges as a critical driver of CRC progression, yet its global…

Date: 2025-09-25

Stroke knowledge and attitudes influence early hospital arrival in acute ischemic stroke: a multicenter cross-sectional survey from Hubei Province, China

Abstract: Prehospital delay remains a major challenge in China and is a critical barrier to timely intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS).…

Date: 2025-09-25

Medication adherence trajectory and its impact on recurrent stroke after carotid artery stenting

Abstract: Medication adherence is critical for patient outcomes, but remains insufficiently investigated in individuals following Carotid Artery Stenting (CAS). This study aims to…

Date: 2025-09-25

Pro-inflammatory S100A9 contributes to retinal ganglion cell degeneration in glaucoma

Abstract: S100A9 is a pro-inflammatory protein involved in neuroinflammation and central nervous system (CNS) neurodegenerative diseases, such as Alzheimer’s and Parkinson’s…

Date: 2025-09-25