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Global, regional, and national differences in the incidence and mortality of digestive congenital anomalies from 1990 to 2021, with projections for future trends

Abstract: Digestive congenital anomalies (DCA) remain a major yet unevenly distributed cause of death and disability worldwide. We aimed to quantify global, regional, and national…

Date: 2025-10-14

Propensity score matching analysis of the relationship between allogeneic blood transfusion and postoperative pulmonary complications in scoliosis correction surgery: a retrospective study

Abstract: Surgery is still the treatment of choice for patients with moderate to severe scoliosis, and vertebral column resection can significantly correct scoliosis. However,…

Date: 2025-10-14

Examination of the effect of spinal anesthesia informational video on anxiety level and postoperative analgesia in transurethral resection of prostate

Abstract: To evaluate the effect of an informational video on spinal anesthesia in reducing preoperative anxiety and postoperative analgesic requirements in patients undergoing…

Date: 2025-10-14

Depression and somatization in Turkish migrants in Germany: the role of migration-related stressors

Abstract: Migration-related stressors (MRS), such as loss, cultural conflict, and language barriers, are linked to increased psychological distress. This study investigates the…

Date: 2025-10-14

Augmenting early stroke diagnosis with an eye-tracker

Abstract: Posterior circulation stroke (PCS) presents significant diagnostic challenges due to poorly localizing and non-specific symptoms, such as dizziness, nausea, and…

Date: 2025-10-14

Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells

Abstract: Radioresistance results in relapse and treatment failure in locally advanced colorectal cancer (CRC) patients. HMGB1 is reportedly associated with radioresistance in…

Date: 2025-10-14

Non-additive strong gene interactions cause striking differences in organ pathology and cytokine response in Leishmaniasis

Abstract: The mouse strain O20 is highly resistant to parasite Leishmania major . O20 mice differed from all resistant strains tested until now, as they harbored parasites in…

Date: 2025-10-14

Cost-effectiveness of cadonilimab plus chemotherapy vs chemotherapy alone for advanced gastric cancer: evidence to inform drug pricing in the U.S. and China

Abstract: Cadonilimab, a bispecific antibody targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), was the first agent of its…

Date: 2025-10-14

European experience of patients with HER2-positive advanced/metastatic breast cancer accessing trastuzumab deruxtecan through a named patient program: the EUROPA T-DXd study

Abstract: In January 2021, trastuzumab deruxtecan (T-DXd) received conditional approval in the European Union for the treatment of human epidermal growth factor receptor…

Date: 2025-10-14

Analysis of lymph node recurrence patterns and risk factors in locally advanced esophageal carcinoma following neoadjuvant therapy

Abstract: Although neoadjuvant therapy followed by surgery is the standard treatment for resectable locally advanced esophageal carcinoma, heterogeneity exists in neoadjuvant…

Date: 2025-10-14