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Environmental noise and self-rated health in older surgical patients undergoing general anesthesia: a cross-sectional study of anxiety as a behavioral pathway for healthy aging

Abstract: Promoting healthy aging—a core public-health objective—demands hospital environments that support functional recovery and well-being. Excessive ward noise, however, is a…

Date: 2025-09-29

Electroencephalogram prediction of propofol effects on neuromodulation in disorders of consciousness

Abstract: This study aimed to characterize electroencephalogram (EEG) responses to low-dose propofol anesthesia in patients with disorders of consciousness (DoC) of distinct…

Date: 2025-09-29

Prevalence and associated factors of mental distress among private college nursing students in Gondar town, Northwest Ethiopia, 2023

Abstract: Mental distress (MD) refers to a range of troubling, confusing, or unusual internal experiences and symptoms that affect more than 25% of people during their lives.…

Date: 2025-09-29

Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma

Abstract: Lung adenocarcinoma is the most prevalent lung cancer type, with a 5-year survival rate for advanced patients below 20%. This study aims to develop a risk model to guide…

Date: 2025-09-29

Comparison of efficacy and side effects between short-course radiotherapy and chemotherapy with or without immunotherapy in the neoadjuvant treatment for patients with locally advanced rectal cancer

Abstract: To evaluate the efficacy and safety of short-course radiotherapy (SCRT) combined with chemotherapy (ChT) with or without immunotherapy (IT) in the neoadjuvant treatment…

Date: 2025-09-29

Strategy to select nasopharyngeal cancer patients for adaptive radiotherapy

Abstract: Nasopharyngeal cancer (NPC) patients experience significant anatomical changes during radiation treatment (RT). Adaptive radiotherapy (ART) can be initiated in response…

Date: 2025-09-29

Association between ambient air pollution and outpatient visits for primary acquired lacrimal duct obstruction in Hangzhou, China

Abstract: Primary acquired lacrimal duct obstruction (PALDO) is the most common lacrimal drainage disease in clinics, which can be caused by multiple factors. However, few studies…

Date: 2025-09-29

PD-L1 expression in cerebrospinal fluid for leptomeningeal metastasis from solid tumors: preliminary assessment of clinical implications

Abstract: Intrathecal immune checkpoint inhibitors have shown promise for leptomeningeal metastasis (LM). Programmed cell death ligand 1 (PD-L1) is currently the primary…

Date: 2025-09-29

Real-world disproportionality analysis of cardiac failure associated with novel antineoplastic agents in breast cancer: a pharmacovigilance study

Abstract: Some antineoplastic agents have been implicated in cardiac failure (CF), but large-scale real-world data remain limited. This study aimed to assess disproportional…

Date: 2025-09-29

Dosimetric evaluations using cycle-consistent generative adversarial network synthetic CT for MR-guided adaptive radiation therapy

Abstract: Magnetic resonance (MR) guided radiation therapy combines high-resolution image capabilities of MRI with the precise targeting of radiation therapy. However, MRI does…

Date: 2025-09-29