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Efficacy and safety evaluation of cross-reactive Fibroblast activation protein scFv-based CAR-T cells

Abstract: Introduction: Fibroblast activation protein (FAP) overexpression on cancer-associated fibroblasts (CAFs) is associated with poor prognosis and worse clinical outcomes.…

Date: 2024-07-17

Association between triglyceride glucose body mass index and cardiovascular disease in adults: evidence from NHANES 2011- 2020

Abstract: Background: The association between insulin resistance and cardiovascular diseases (CVD) is of significant interest. However, there is limited published research on the…

Date: 2024-07-16

Discontinuation of afterload-reducing drugs decreases left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy

Abstract: Background: Hypertrophic cardiomyopathy (HCM), the most common genetic heart disease, is classified into hypertrophic non-obstructive and hypertrophic obstructive…

Date: 2024-07-16

Concordance of left ventricular volumes and function measurements between two human readers, a fully automated AI algorithm, and the 3D heart model

Abstract: Background: Echocardiography is essential in cardiovascular medicine for screening, diagnosis, and monitoring. Artificial intelligence (AI) has the potential to improve…

Date: 2024-07-16

The association between composite dietary antioxidant index and diabetic retinopathy in type 2 diabetic patients: evidence from the NHANES

Abstract: Background: Although diabetic retinopathy (DR) is closely related to dietary patterns and oxidative stress, there is little research on the relationship between the…

Date: 2024-07-16

Genotype-relevant neuroimaging features in low-grade epilepsy-associated tumors

Abstract: Introduction: Low-grade epilepsy-associated tumors are the second most common histopathological diagnoses in cases of drug-resistant focal epilepsy. However, the…

Date: 2024-07-16

Applying a clinical staging model in patients affected by schizophrenia spectrum disorder

Abstract: Background: Clinical staging, already widespread in medicine, represents a new frontier in psychiatry. Our goal was to convert the existing theoretical staging model for…

Date: 2024-07-16

Association between serum osmolality and 28-day all-cause mortality in patients with heart failure and reduced ejection fraction: a retrospective cohort study from the MIMIC-IV database

Abstract: Background: Previous studies have not thoroughly explored the impact of serum osmolality levels on early mortality in heart failure and reduced ejection fraction (HFrEF)…

Date: 2024-07-15

The inotropic and arrhythmogenic effects of acutely increased late INa are associated with elevated ROS but not oxidation of PKARI?

Abstract: Background: Acute stimulation of the late sodium current (INaL) as pharmacologically induced by Anemonia toxin II (ATX-II) results in Na+-dependent Ca2+ overload and…

Date: 2024-07-15