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E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the ?-catenin/HIF-1? positive feedback loop in chronic rhinosinusitis with nasal polyps

Abstract: Chronic rhinosinusitis with nasal polyp (CRSwNP) is a refractory inflammatory disease with epithelial-mesenchymal transition (EMT) as one of the key features. Since…

Date: 2023-12-05

An integrative evaluation of circadian gene TIMELESS as a pan-cancer immunological and predictive biomarker

Abstract: The gene TIMELESS, which is involved in the circadian clock and the cell cycle, has recently been linked to various human cancers. Nevertheless, the association between…

Date: 2023-12-05

Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors

Abstract: As the incidence of neuroendocrine tumors has been rising, gender differences in epidemiology and clinical behavior have emerged, and interest into a gender-driven…

Date: 2023-12-05

What to do with non-responders to CGRP(r) monoclonal antibodies: switch to another or move to gepants?

Abstract: In this editorial we aim to provide potential therapeutic options in patients who do not benefit from treatment with CGRP(r) monoclonal antibodies. Based on current…

Date: 2023-12-05

Associations of medicine use and ejection fraction with the coexistence of frailty and sarcopenia in a sample of heart failure outpatients: a cross-sectional study

Abstract: Frailty and sarcopenia have been extensively studied in heart failure (HF) patients, but their coexistence is unknown. The aim of this work is to describe the…

Date: 2023-12-05

The adverse outcome pathway for breast cancer: a knowledge management framework bridging biomedicine and toxicology

Abstract: Breast cancer is the most common cancer worldwide, with an estimated 2.3 million new cases diagnosed every year. Effective measures for cancer prevention and cancer…

Date: 2023-12-05

Follow-up assessment of sleep-related symptoms in patients after treatment for cancer: responses to continuous positive airway pressure treatment for co-morbid obstructive sleep apnoea

Abstract: To assess changes in sleep-related symptoms in patients with breast cancer, endometrial cancer and melanoma previously examined for sleep-related symptoms and the…

Date: 2023-12-05

Breast Cancer in Pakistan: Screening and Detection

Abstract: Breast cancer is a major health issue with over 2 million new cases diagnosed annually. The burden of this disease is much higher in low- to middle-income countries…

Date: 2023-12-05

Fibronectin glomerulopathy in a kidney allograft biopsy

Abstract: Fibronectin glomerulopathy is a rare genetic nephropathy with only a few cases of post-transplant recurrence being reported previously. We highlight a case that was…

Date: 2023-12-05

Effects of different therapy regimens to increase final adult height in males at advanced bone age with idiopathic short stature

Abstract: This retrospective study explored the effect on adult height of a combination of recombinant human growth hormone (rhGH) and aromatase inhibitors (AIs), or rhGH and a…

Date: 2023-12-05