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Building an interpretable machine learning prognosis prediction model-based on baseline examinations of patients with esophageal cancer undergoing surgery

Abstract: To create an interpretable machine learning model based on non-invasive biomarkers for the early diagnosis and improved prognostic value of esophageal cancer. We…

Date: 2026-08-14

Targeted therapy plus chemotherapy for advanced or metastatic triple-negative breast cancer: a PRISMA 2020 systematic review and meta-analysis

Abstract: To systematically review the efficacy of chemotherapy combined with targeted therapy in the handling of advanced triple-negative breast cancer (TNBC). A thorough…

Date: 2026-08-14

Metabolic, inflammatory, and lipoprotein(a)-related risk profiling for incident ASCVD: a multi-biomarker study

Abstract: Metabolic dysfunction, inflammation, and lipoprotein(a) [Lp(a)] reflect different biomarker domains associated with atherosclerotic cardiovascular disease (ASCVD) risk.…

Date: 2026-08-14

A retrospective study on the impact of SARS-CoV-2 infection on cardiopulmonary function in a healthy Chinese cohort: a focus on “long COVID”

Abstract: This retrospective study aimed to observe the cardiopulmonary function and lingering symptoms in previously healthy individuals with Long COVID using Cardiopulmonary…

Date: 2026-08-14

Osteopetrorickets and calcium homeostasis in children with osteopetrosis: an endocrinological single-center study

Abstract: Osteopetrosis is a rare inherited disorder caused by impaired osteoclast number or function, leading to increased bone density, fractures, neurologic complications, and…

Date: 2026-08-13

Real-world retrospective analysis of clinical outcomes in pediatric acquired aplastic anemia: a single-center 10-year cohort study

Abstract: Pediatric aplastic anemia (AA), a rare and potentially fatal disease, demonstrates significant heterogeneity in pathogenesis, disease severity, therapeutic regimens, and…

Date: 2026-08-13

Chronic insomnia is associated with inflammatory, carotid atherosclerotic, MRI-based brain atrophy-related, and cognitive alterations: the potential role of IL-6

Abstract: This study aimed to investigate the co-occurrence patterns of inflammatory, carotid atherosclerotic, MRI-based brain atrophy-related, and cognitive alterations in…

Date: 2026-08-13

Stability-aware LSTM–MPC framework for personalized levothyroxine dosing in Hashimoto’s thyroiditis

Abstract: Hypothyroidism, most commonly caused by Hashimoto’s thyroiditis, is characterized by insufficient production of thyroid hormones and is typically treated with oral…

Date: 2026-08-13

NR5A1 gene variants: variable phenotypes, new variants, and genotype-phenotype correlations

Abstract: NR5A1 variants are among the most frequent monogenic causes of disorders of sex development (DSD). However, genotype–phenotype correlations remain unclear, and…

Date: 2026-08-13

Universal versus risk– factor–based screening for gestational diabetes mellitus: findings from a large–scale cohort study

Abstract: Gestational diabetes mellitus (GDM) carries significant feto-maternal risks. While early diagnosis and treatment effectively mitigate these adverse outcomes, the most…

Date: 2026-08-13