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Development and internal validation of an inflammation-platelet synergy score for anterior circulation cerebral infarction: an exploratory case-control study

Abstract: Inflammatory and thrombotic pathways interact in atherothrombotic stroke pathogenesis, yet combined assessment of these markers for distinguishing patients with anterior…

Date: 2026-07-16

Immune network dysregulation in rheumatoid arthritis and systemic lupus erythematosus: cytokine signatures, autoantibody profiles, and implications for precision medicine

Abstract: Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are systemic autoimmune diseases characterized by chronic inflammation, immune dysregulation, and…

Date: 2026-07-16

Trends and disparities in deaths involving atherosclerotic cardiovascular disease and stroke-related conditions among U.S. adults, 1999–2025

Abstract: ASCVD and stroke remain leading causes of death in the United States, sharing overlapping risk factors and clinical consequences. Long-term declines in vascular…

Date: 2026-07-16

Identification and validation of an explainable prediction model of favorable outcome under integrative medicine treatment exposure in DKD adult patients: a retrospective cohort study

Abstract: Diabetic kidney disease (DKD) shows heterogeneous responses to integrative medicine treatment (IMT). A critical unmet need in DKD management is the inability to predict…

Date: 2026-07-16

BMI-stratified nomograms to predict early SIRS-defined sepsis after flexible ureteroscopy

Abstract: Postoperative sepsis is a serious complication of flexible ureteroscopy (FURS). Body mass index (BMI) may modify risk, but BMI-stratified prediction models are lacking.…

Date: 2026-07-16

CACUL1 promotes hepatocellular carcinoma progression through enhanced tumor cell proliferation and macrophage-mediated immune suppression

Abstract: Although cullin-family E3 ubiquitin ligases regulate diverse oncogenic pathways, the role of CACUL1 in hepatocellular carcinoma (HCC) remains poorly characterized. We…

Date: 2026-07-16

The prognostic significance of immunohistochemical expressions of proliferating cell nuclear antigen, P16 and Ki-67 in breast cancer

Abstract: This study investigates the link between proliferation markers (PCNA, p16, Ki-67) and histopathological factors, exploring their prognostic value in breast cancer…

Date: 2026-07-16

Development and validation of a nomogram to predict symptomatic recurrence following laparoscopic adenomyomectomy

Abstract: Nomograms are intuitive graphical tools that integrate multiple prognostic variables to generate individualized risk estimates. To date, no study has developed a…

Date: 2026-07-16

Maternal health literacy status and associated factors among pregnant women: a cross-sectional study in Chongqing, China

Abstract: Maternal health literacy (MHL) plays a critical role in improving perinatal outcomes. This study aimed to investigate MHL status and its associated factors among…

Date: 2026-07-16

Surgical decision-making for primary stress urinary incontinence: insights from a nationwide survey of gynecologists in Turkey

Abstract: To delineate the surgical preferences of gynecologists in the management of primary stress urinary incontinence (SUI) and to explore the extent to which clinical…

Date: 2026-07-16