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LOXL1, THY1, and TYMS define an annotation-derived hemoglobin-associated immunotranscriptomic signature in osteoarthritis cartilage

Abstract: Osteoarthritis (OA) is increasingly recognized as a whole-joint disease involving cartilage degeneration, synovial inflammation, subchondral bone remodeling, and…

Date: 2026-07-09

Non-rotational medial pinning with the K-Hammer technique in pediatric supracondylar fractures: a retrospective case-control study

Abstract: Pediatric Gartland type III–IV extension-type supracondylar humeral fractures are associated with a risk of iatrogenic ulnar nerve injury during medial percutaneous pin…

Date: 2026-07-09

Clinical correlates of lipoprotein (a) and apolipoprotein B levels in patients with dyslipidemia and cardiovascular disease

Abstract: Atherosclerotic cardiovascular disease remains a major cause of morbidity and mortality worldwide, with residual cardiovascular risk persisting despite optimized…

Date: 2026-07-09

Association of IL4I1 + M2-like macrophages in tumor microenvironment with poor prognosis in hepatocellular carcinoma: insights from bioinformatics and experimental validation

Abstract: Hepatocellular carcinoma (HCC) is associated with poor prognosis and limited responses to immunotherapy, partly due to the immunosuppressive tumor microenvironment…

Date: 2026-07-09

Generative adversarial networks for balancing and expanding data resources for computer-aided detection in colonoscopy

Abstract: Developing computer-aided detection (CADe) algorithms in colonoscopy requires high-quality databases sourced from real-world data. However, such databases demand costly…

Date: 2026-07-09

Serum immune profiling suggests overlap between IBD patients with joint complaints and patients with spondyloarthritis

Abstract: Inflammatory bowel disease (IBD) and spondyloarthritis (SpA) are strongly associated, and joint complaints are common in patients with IBD. However, it remains unclear…

Date: 2026-07-09

Unique expression pattern of circulating exosomal miRNA correlates with CNS pathology

Abstract: To investigate the total circulating exosome transcriptome in animal models of two different CNS pathologic conditions, autoimmune demyelination and traumatic brain…

Date: 2026-07-09

GATD3A-mediated monocyte homeostasis and compartmentalized erythrocyte alpha-synuclein discriminate early Parkinson’s disease from MSA-P

Abstract: Differentiating early-stage Parkinson’s disease (PD) from the parkinsonian variant of multiple system atrophy (MSA-P) remains a significant challenge due to overlapping…

Date: 2026-07-09

Early arterial blood gas parameters, clinical features, and neuroimaging findings in neonates undergoing therapeutic hypothermia for suspected hypoxic-ischemic encephalopathy: a retrospective single-center study

Abstract: Hypoxic-ischemic encephalopathy (HIE) remains an important cause of neonatal mortality and long-term neurodevelopmental impairment. Although therapeutic hypothermia is…

Date: 2026-07-09

Early prediction of severe autoimmune encephalitis: development and validation of a model incorporating readily available lactate dehydrogenase

Abstract: Autoimmune encephalitis (AE) is a severe neuroinflammatory disease with a substantial risk of progression to critical illness requiring intensive care. Early…

Date: 2026-07-09