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RNF213 marks a regulatory T-cell subset associated with ulcerative colitis

Abstract: Ulcerative colitis (UC) is a nonspecific autoimmune disease, the etiology and pathogenesis of which remain unclear. Identifying new disease targets could inform clinical…

Date: 2026-07-06

Correlations of systemic immune-inflammation index and systemic inflammation response index with the risk for early-onset post-stroke depression in patients with minor stroke: a prospective observational study

Abstract: Inflammation plays a pivotal role in the pathophysiology of post-stroke depression (PSD). However, the relationship between novel systemic inflammatory indices-the…

Date: 2026-07-06

Borrelia miyamotoi infection negatively impacts pregnancy outcomes in immunodeficient mice

Abstract: Soft tick relapsing fever (RF) infections cause adverse pregnancy outcomes, but the impact of hard tick RF on pregnancy is unknown. We assessed pregnancy outcomes in a…

Date: 2026-07-06

Psychological burden in anaphylaxis: a study on alexithymia and quality of life

Abstract: This study examines the impact of psychological burden on quality of life (QoL) in patients with anaphylaxis, assessing the relationship between alexithymia, QoL, and…

Date: 2026-07-06

Economic value of finotonlimab plus bevacizumab versus sorafenib for first-line treatment of unresectable hepatocellular carcinoma in China and the United States

Abstract: Finotonlimab combined with bevacizumab demonstrated superior progression-free survival and overall survival compared with sorafenib in patients with unresectable…

Date: 2026-07-06

Assessing the risk of adverse drug events from combining aromatase inhibitors with CDK4/6 inhibitors using the FAERS and JADER databases

Abstract: Reports of adverse drug events (ADEs) involving aromatase inhibitors (AIs) and cyclin-dependent kinase 4/6 (CDK4/6) inhibitors exist, but a comprehensive assessment of…

Date: 2026-07-06

Target-prioritized IMRT for nasopharyngeal carcinoma with tumor proximity to the spinal cord: clinical feasibility and long-term outcomes

Abstract: For locally advanced nasopharyngeal carcinoma (NPC) with tumor close to the cervical spinal cord, strict spinal cord constraints may compromise target coverage. We…

Date: 2026-07-06

Longitudinal changes in the relative toxicity of FDA-approved oncology therapeutics: evidence from paired initial and updated RCT reports

Abstract: A growing share of oncology drugs receive FDA approval via expedited pathways based on interim RCT analyses, leaving safety data relatively immature at approval. Whether…

Date: 2026-07-06

From proteome-wide Mendelian randomization and multi-omics integration to functional validation: TGFB3 as a prioritized candidate in gastric adenocarcinoma

Abstract: Gastric adenocarcinoma lacks robust circulating biomarkers and tractable targets. We assessed whether genetically predicted plasma protein levels influence disease risk…

Date: 2026-07-06

The effects of brain radiotherapy combined with immunotherapy and chemotherapy for driver gene-negative non-small-cell lung cancer with brain metastases

Abstract: Brain metastases (BM) are highly prevalent in advanced non-small cell lung cancer (NSCLC); however, therapeutic options remain limited and suboptimal for driver…

Date: 2026-07-06