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Impact of opioid agonist therapies on non-fatal and fatal overdose: treatment patterns among individuals with opioid use disorder in Ontario, Canada

Abstract: Although opioid agonist therapies (OAT) including buprenorphine extended-release (BUP-XR), transmucosal buprenorphine (TM-BUP), methadone and slow-release oral morphine…

Date: 2026-09-29

Beyond community state types: vaginal microbial diversity and CST-IV signatures are associated with pregnancy in euploid embryo transfer cycles

Abstract: Despite significant progress in assisted reproductive technology, in vitro fertilization (IVF) pregnancy rates remain suboptimal. Although the vaginal microbiome has…

Date: 2026-09-29

Seasonal ambient temperature and particulate matter as discriminators of hyperemesis gravidarum severity: a retrospective comparative observational study

Abstract: Ambient air pollutants and temperature may influence the clinical severity of hyperemesis gravidarum (HG), but their relative contributions remain unclear. This study…

Date: 2026-09-29

Trans-cuff budesonide delivery and its effects on endotracheal intubation-induced subglottic injury

Abstract: This study aimed to determine whether budesonide inhalation suspension (BIS) diffuses through polyvinyl chloride (PVC) endotracheal tube (ETT) cuffs and whether…

Date: 2026-09-29

Virtual reality-assisted psychological treatment of aggression for violent offenders: a pilot descriptive case series in maximum-security forensic psychiatry

Abstract: Aggressive behaviour remains a major clinical challenge in forensic psychiatric care, and effective interventions targeting aggression are limited. Virtual Reality…

Date: 2026-09-29

Suicide attempt risk in autism: a national EHR study of 2.3 million individuals

Abstract: Suicide attempts (SA) are elevated in individuals with autism spectrum disorder (ASD), but population-level data characterizing how SA prevalence varies across…

Date: 2026-09-29

Combined scleral suture-fixated intraocular lens implantation and Iris cerclage pupilloplasty for aphakic eyes with traumatic mydriasis

Abstract: The aim of this study was to present the observational outcomes of scleral suture-fixated intraocular lens (IOL) implantation combined with iris cerclage pupilloplasty…

Date: 2026-09-29

SPHK1 drives pyroptosis via ROS-dependent activation of the NLRP3 inflammasome in non-infectious uveitis

Abstract: Non-infectious uveitis associated with systemic diseases is a sight-threatening inflammatory disorder often associated with dysregulated immune responses and oxidative…

Date: 2026-09-29

Cross-modal fusion of OCT and OCT angiography enface for improved diagnostics of diabetic retinopathy

Abstract: Diabetic retinopathy (DR) is a leading cause of vision impairment worldwide, highlighting the need for accurate and accessible screening tools. Optical Coherence…

Date: 2026-09-29

Orbital decompression with intraorbital corticosteroid injection during the active phase of thyroid eye disease: outcomes in a real-world cohort

Abstract: Orbital decompression is an effective surgery for reducing orbital congestion and proptosis for patients with thyroid eye disease (TED). However, it is commonly stated…

Date: 2026-09-29