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Identification of Crohn’s disease-associated molecular signatures by integrative bioinformatics analysis and experimental validation

Abstract: Crohn’s disease (CD) is a chronic inflammatory bowel disease with rising global incidence. Its multifactorial etiology involves genetic, environmental, microbial, and…

Date: 2026-09-29

Integrative single-cell and bulk transcriptomic analysis identify R-loop-associated gene signatures driving immune-inflammatory networks in acute pancreatitis

Abstract: R-loop dysregulation has been implicated in chronic inflammation via DNA damage and cytoplasmic ssDNA release, yet its role in acute pancreatitis (AP) remains to be…

Date: 2026-09-29

Vitamin D screening and targeted supplementation delays liver fibrosis in patients with chronic liver disease: A prospective randomized controlled trial

Abstract: This study aimed to assess the effects of vitamin D screening and targeted supplementation on the progression of liver fibrosis in patients with chronic liver disease…

Date: 2026-09-29

Real-world effectiveness and safety of lasmiditan in patients with migraine: an observational study

Abstract: To evaluate the real-world effectiveness and safety of lasmiditan and determine the factors associated with its effectiveness and adverse effects. We evaluated 75…

Date: 2026-09-29

Multi-modal spatial glycomic analysis of lymphoid aggregates in prostate and pancreatic cancer tissues

Abstract: Altered N-glycosylation plays a critical role in immune regulation, yet the spatial distribution of N-glycans within immune niches of immunologically “cold” tumors…

Date: 2026-09-29

Serum NLRP3 levels are associated with postoperative delirium of elderly patients with lung cancer: an observational analytical study

Abstract: NOD-like receptor protein 3 (NLRP3) regulates the inflammatory response. This study aimed to investigate the relationship between perioperative serum NLRP3 levels and…

Date: 2026-09-29

Fluoropyrimidine-associated gastrointestinal toxicity: pharmacovigilance reporting signals and in vitro evidence of epithelial injury, barrier impairment, and inflammatory responses

Abstract: Fluoropyrimidines, including 5-fluorouracil (5-FU), capecitabine, tegafur, and trifluridine, are widely used anticancer agents, but their gastrointestinal toxicities…

Date: 2026-09-29

National trends and disparities in mortality involving bladder cancer and substance use disorders in the United States, 1999–2023

Abstract: Although bladder cancer mortality has modestly declined in the United States, co-occurring substance use disorders (SUDs) may contribute to adverse outcomes and widening…

Date: 2026-09-29

Selective rolling circle amplification detection of site-specific DNA 5-hydroxymethylcytosine

Abstract: Site-specific 5-hydroxymethylcytosine (5hmC) has been identified as a potential biomarker involving diagnosis, prognosis, and tumor immune microenvironment across…

Date: 2026-09-29

Context-dependent value of HLA class I diversity in advanced non-small cell lung cancer treated with immune checkpoint blockade

Abstract: Immune checkpoint inhibitors (ICI), alone or in combination with chemotherapy, are the standard first-line treatment for advanced non–small cell lung cancer (NSCLC)…

Date: 2026-09-29