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CTSG-expressing mast cells confer resistance to immunotherapy in colorectal cancer

Abstract: Mast cells are increasingly recognized as an important regulator of the tumor microenvironment. However, their role in colorectal cancer (CRC) is controversial, and…

Date: 2026-07-01

Clinical efficacy analysis of acupuncture combined with anti-tumor necrosis factor treatment for spleen and kidney yang deficiency type ulcerative colitis

Abstract: This study aims to investigate the clinical effects of acupuncture combined with tumor necrosis factor inhibitors in treating spleen-kidney yang deficiency type…

Date: 2026-07-01

Evaluation of eradication efficacy and optimization strategies for Helicobacter pylori infection based on real-world data: a multivariable retrospective study

Abstract: Based on real-world clinical data, this study aims to evaluate the differences in eradication efficacy among various H. pylori treatment regimens and the impact of…

Date: 2026-07-01

Endoscopic mucosal resection versus endoscopic submucosal dissection for early colorectal cancer and precursor lesions: a retrospective study

Abstract: Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are both used for early colorectal cancer (CRC) and precursor lesions, but optimal size…

Date: 2026-07-01

Duodenal dysbiosis is linked to altered ferroportin related transcriptomics programs in iron deficiency anemia

Abstract: Iron deficiency anemia (IDA) affects over two billion people, yet up to half of patients show inadequate response to oral iron therapy. We hypothesized that IDA is a…

Date: 2026-07-01

Impact of reperfusion on thrombectomy outcomes in patients with pre-stroke disability

Abstract: Mechanical thrombectomy (MT) is frequently performed beyond traditional eligibility criteria, yet the clinical benefits for patients with pre-stroke disability remain…

Date: 2026-07-01

Dynamic changes and associated factors of asymmetric prominent vessel sign in atherosclerotic anterior circulation acute ischemic stroke: a preliminary study

Abstract: To investigate the dynamic changes, influencing factors, and prognostic significance of the asymmetric prominent vessel sign (APVS) in patients with atherosclerotic…

Date: 2026-07-01

Burden level and influencing factors of caregivers for patients with autoimmune encephalitis

Abstract: Caregiver burden is a critical issue in neurological disorders, but remains underexplored in autoimmune encephalitis (AE), a severe condition on patients and their…

Date: 2026-07-01

Regional disparities and hospital performance patterns in acute stroke reperfusion: a multicenter study in Sichuan Province, China

Abstract: Timely reperfusion is critical to improving outcomes in acute ischemic stroke (AIS). However, disparities in treatment quality and accessibility persist across hospital…

Date: 2026-07-01

Cognitive impairment in Chinese patients with isolated generalized dystonia: a case–control study

Abstract: Previous studies have indicated that non-motor symptoms are primary problems in focal dystonia, but limited data are available about cognitive function and their…

Date: 2026-07-01